AI Article Synopsis
- This study investigates the link between genetic variations AGTR1 (rs5186) and TGF-β1 (rs1800470) and the risk of developing diabetic nephropathy (DN) in type 2 diabetes patients compared to those without DN and healthy individuals.
- A case-control study with 165 participants (including 59 with DN, 54 without DN, and 52 healthy controls) found that DN patients had significantly higher levels of various clinical parameters.
- The results indicated that specific risk alleles and genotypes were significantly more common in DN patients, suggesting a strong genetic association with the risk of developing diabetic nephropathy in those with type 2 diabetes.
Article Abstract
Background/aims: Diabetic nephropathy (DN) is one of the complications of diabetes mellitus (DM). This study aimed to investigate the association between genetic polymorphisms, specifically AGTR1 (rs5186) and TGF-β1 (rs1800470), and the risk of developing Diabetic nephropathy (DN) in type 2 diabetes mellitus patients, compared to those without DN and healthy controls.
Methods: A case-control study was conducted on 165 diabetic patients (59 with diabetic nephropathy (DN) and 54 without DN (DM)), and 52 healthy controls (HC). The genotyping was done using amplification refractory mutation system method (ARMS-PCR). Age, gender, and duration of diabetes were matched across groups. Clinical parameters including FBS, RBS, HbA1C, creatinine, urea, SBP, DBP, total cholesterol, triglycerides, LDL, and BMI were assessed.
Results: Diabetic patients with nephropathy exhibited significantly higher levels of clinical parameters compared to those without nephropathy and healthy controls. The risk allele of , C ( <0.0001), and risk allele containing genotypes AC ( <0.0001) and CC ( - 0.0010) were significantly higher in DN patients compared to DM and HC groups. Similarly, the risk allele C ( - 0.0001), and corresponding genotypes TC ( - 0.0038) and CC ( - 0.0027) were significantly associated with increased risk of diabetic nephropathy compared to DM and HC groups.
Conclusion: The data showed significant association of (rs5186) and (rs1800470) polymorphism with an increased risk of diabetic nephropathy in type 2 diabetes mellitus patients. More investigation will be required to disseminate the results, while increasing the samples size and using whole genome sequencing.
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