Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor binding modes of multiple alphaviruses to understand their ability to infect a wide range of hosts. We further discuss the challenges associated with the development of broad-spectrum treatment strategies against a diverse range of alphaviruses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11162471 | PMC |
| http://dx.doi.org/10.1038/s41467-024-49301-1 | DOI Listing |
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