AI Article Synopsis
- Free-field blast exposure leads to complex brain responses, potentially causing long-lasting neurological issues.
- The study focused on how different pressures from blasts affect intracranial pressure (ICP) in rats, revealing that these effects vary across different brain locations regardless of the blast's strength.
- The research highlights the importance of understanding ICP characteristics for improving modeling in future studies of brain injuries caused by blasts.
Article Abstract
Free-field blast exposure imparts a complex, dynamic response within brain tissue that can trigger a cascade of lasting neurological deficits. Full body mechanical and physiological factors are known to influence the body's adaptation to this seemingly instantaneous insult, making it difficult to accurately pinpoint the brain injury mechanisms. This study examined the intracranial pressure (ICP) profile characteristics in a rat model as a function of blast overpressure magnitude and brain location. Metrics such as peak rate of change of pressure, peak pressure, rise time, and ICP frequency response were found to vary spatially throughout the brain, independent of blast magnitude, emphasizing unique spatial pressure fields as a primary biomechanical component to blast injury. This work discusses the ICP characteristics and considerations for finite element models, in vitro models, and translational in vivo models to improve understanding of biomechanics during primary blast exposure.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11402848 | PMC |
| http://dx.doi.org/10.1007/s10439-024-03544-7 | DOI Listing |
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