AI Article Synopsis
- The study examined the risk of developing epilepsy following an episode of transient global amnesia (TGA) using data from the Korean National Health Insurance Service from 2002 to 2020.
- Researchers found that patients with TGA had a significantly higher rate of epilepsy compared to those without TGA, with an adjusted hazard ratio indicating a 46% higher risk.
- Factors such as age, sex, hypertension, diabetes, mental health conditions, and socioeconomic status were identified as significant contributors to the likelihood of developing epilepsy in TGA patients.
Article Abstract
Purpose: This study aimed to investigate the risk of epilepsy after transient global amnesia (TGA).
Methods: Study population was recruited using the International Classification of Diseases codes from the Korean National Health Insurance Service database between 2002 and 2020. The incidence of epilepsy was compared between the TGA (n=12,390) and non-TGA (n=33,868) groups, determined using 1:3 propensity score matching. Using Cox proportional hazard regression model, we obtained adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for incident epilepsy in the TGA compared with non-TGA group. Logistic regression was performed to examine the independent variables determining incident epilepsy in the TGA group, and adjusted odds ratios (aORs) and 95% CIs were calculated.
Results: The TGA group had a significantly higher cumulative incidence of epilepsy than controls (p <0.001, log-rank test). TGA was significantly associated with incident epilepsy in the Cox model (adjusted HR 1.46, 95% CI 1.36-1.56). The adjusted logistic regression showed that age (per 1 year, aOR 1.02, 95% CI 1.01-1.02), female sex (aOR 0.68, 95% CI 0.60-0.77), hypertension (aOR 1.14, 95% CI 1.00-1.30), diabetes (aOR 1.26, 95% CI 1.10-1.44), stroke (aOR 1.22, 95% CI 1.06-1.40), depression (aOR 1.44, 95% CI 1.22-1.69), anxiety (aOR 1.31, 95% CI 1.14-1.51), alcohol-related disease (aOR 1.96, 95% CI 1.38-2.78), low income (aOR 1.18, 95% CI 1.02-1.36) and rural residence (aOR 1.20, 95% CI 1.02-1.42) were associated with incident epilepsy.
Conclusions: Our results suggest a longitudinal association of TGA with incident epilepsy.
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| http://dx.doi.org/10.1016/j.clineuro.2024.108357 | DOI Listing |
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