The halocarbon BCF was tested in 3 assays to assess its mutagenicity and clastogenicity. It produced a positive response in Salmonella typhimurium strain TA1535 but was negative in TA1537, TA1538, TA98 and TA100. In an L5178Y mouse lymphoma microwell assay (TK locus), BCF was negative. BCF was administered at 5000 and 50 000 ppm in air for 6 h to groups of C57B1/6J mice of both sexes. Animals were killed at 24, 48 and 72 h after cessation of exposure and the incidence of bone marrow micronuclei per 1000 PCEs determined. There was no significant difference in the incidences of micronuclei between untreated animals and those exposed to either concentration of BCF at any of the sampling times. These results suggest that BCF is mutagenic in vitro in only one strain of Salmonella; in mammalian cells the compound induced no gene mutation in vitro nor clastogenic activity in vivo at doses that also produced clear evidence of toxicity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0165-7992(85)90021-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring the mechanisms of cadmium tolerance and bioaccumulation in a soil amoeba.
Sci Total Environ
January 2025
School of Environmental Science and Engineering, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510006, China. Electronic address:
Cadmium (Cd) pollution is a global concern. Protists represent a prevalent yet understudied group in soil ecosystems, but our understanding of how protists interact with Cd remains limited. This study investigates the interaction between Cd and the soil amoeba Dictyostelium discoideum, focusing on its resistance, accumulation, and molecular mechanisms.
View Article and Find Full Text PDFA Prospective Comparison of Outcomes of Brachiocephalic Versus Brachiobasilic Fistulas for Hemodialysis.
Indian J Nephrol
July 2024
Department of Vascular Surgery, Christian Medical College Vellore, Vellore, Tamil Nadu, India.
Background: Brachiocephalic fistula (BCF) and brachiobasilic fistula (BBF) are autogenous fistulas created in the arm for hemodialysis access. However, despite the differences in anatomy and surgical technique, the existing literature shows no significant statistical difference between the maturation, patency, or complications. We analyzed the outcomes of these two types of arteriovenous fistulas in our subgroup of the Indian population.
View Article and Find Full Text PDFElemental partitioning, morpho-physiological effects, genotoxicity, and health risk assessment associated with tomato (Solanum lycopersicum L.) grown in soil contaminated with mining tailings.
Environ Res
January 2025
Doctorado en Ciencias Ambientales, Centro de Ciencias de Desarrollo Regional, Universidad Autónoma de Guerrero. Privada de Laurel 13, Col. El Roble, 39640, Acapulco, Guerrero, México; Facultad de Ciencias Agropecuarias y Ambientales, Unidad Tuxpan, Universidad Autónoma de Guerrero. Carretera Iguala-Tuxpan, km 2.5, Iguala de la Independencia, Guerrero, México; Facultad de Ciencias Agropecuarias, Universidad Autónoma del Estado de Morelos. Avenida Universidad 1001, 62210, Cuernavaca, Morelos, México; Laboratorio de Toxicología Ambiental, Departamento de Ciencias Ambientales, Instituto de Ciencias de la Atmósfera y Cambio Climático, Universidad Nacional Autónoma de México, Ciudad Universitaria Coyoacán, Ciudad de México 04510, México; Centro Nacional de Recursos Genéticos, Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, Tepatitlán de Morelos, 47600, Jalisco, México; Escuela Superior de Ciencias de la Tierra, Universidad Autónoma de Guerrero. Ex-hacienda de San Juan Bautista, Taxco el Viejo, 40323, Taxco el Viejo, Guerrero, México. Electronic address:
This study explored the distribution of macronutrients (Ca, Mg, Na, K) and lithogenic (Ba, Cr, Ni, Mn, Fe) and mining-related (As, Pb, Cd, Cu, Zn) toxic metalloids and metals (TMMs) in tomato (Solanum lycopersicum L.), and its effects on plant development, productivity, genotoxicity, and human health, using a soil affected by mine tailings (AS) and an unaffected control soil (CS). The chemistry of soils reflected their mineralogy, and Fe-Ti oxides, sulfides and sulfosalts were found to be the most significant reservoirs of TMMs.
View Article and Find Full Text PDFIntegrative study of subcellular distribution, chemical forms, and physiological responses for understanding cadmium tolerance in two garden shrubs.
J Plant Physiol
January 2025
Beijing Forestry University, National Engineering Research Center for Floriculture, Beijing Laboratory of Urban and Rural Ecological Environment, Beijing, 100083, China. Electronic address:
Urban ornamental shrubs have significant potential for restoring cadmium (Cd)-contaminated soil. The Cd enrichment characteristics and tolerance mechanisms of Buxus sinica and Ligustrum × vicaryi were investigated through a simulated pot pollution experiment. Specifically, the Cd content and accumulation in different plant tissues, the subcellular distribution and chemical forms of Cd in the roots, and the effects of Cd on the ultrastructure of root cells under various Cd concentrations (0, 25, 50, 100, and 200 mg kg⁻) were analyzed.
View Article and Find Full Text PDFEvaluating the Protective Effects of MitoQ and Antifreeze Protein III on Cryopreserved Canine Sperm.
Animals (Basel)
January 2025
Veterinary Clinic for Reproductive Medicine and Neonatology, Justus-Liebig-University of Giessen, 35392 Giessen, Germany.
Cryopreservation can adversely affect sperm motility, structural integrity, and fertilization ability. This study investigated the effects of MitoQ and antifreeze protein III (AFP III) on frozen-thawed semen from eight adult dogs using a Tris-fructose extender. Ejaculates were divided and diluted with a standard Tris-fructose-egg yolk extender containing MitoQ (200 nM/mL) and AFP III (0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!