AI Article Synopsis
- - Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by the loss of dopaminergic neurons, and there's a critical need for new therapies that can halt or reverse its progression, making gene therapy a promising option to explore.
- - A systematic review evaluated the safety and effectiveness of gene therapy in PD by analyzing studies from databases like PubMed and Cochrane, with an emphasis on bias assessment and the neuroprotective potential of these treatments, which could repair neuronal damage and improve brain circuit function rather than just alleviating symptoms.
- - The results suggest that gene therapy might offer advantages over traditional treatments, including reduced side effects, improved symptom relief, and more effective dopamine replacement; however, the need for more
Article Abstract
Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the brain. Despite existing treatments, there remains an unmet need for therapies that can halt or reverse disease progression. Gene therapy has been tried and tested for a variety of illnesses, including PD. The goal of this systematic review is to assess gene therapy techniques' safety and effectiveness in PD clinical trials.
Methods: Online databases PubMed/Medline, and Cochrane were used to screen the studies for this systematic review. The risk of bias of the included studies was assessed using standard tools.
Results: Gene therapy can repair damaged dopaminergic neurons from the illness or deal with circuit anomalies in the basal ganglia connected to Parkinson's disease symptoms. Rather than only treating symptoms, this neuroprotective approach alters the illness itself. Medication for gene therapy is currently administered at the patient's bedside. It can hyperactivate specific brain circuits associated with motor dysfunction. PD therapies are developing quickly, and there aren't enough head-to-head trials evaluating the safety and effectiveness of available treatments. When choosing an advanced therapy, patient-specific factors should be considered in addition to the effectiveness and safety of each treatment option.
Conclusion: In comparison to conventional therapies, gene therapy may be advantageous for PD. It may minimize side effects, relieve symptoms, and offer dependable dopamine replacement.
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| http://dx.doi.org/10.1016/j.disamonth.2024.101754 | DOI Listing |
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