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Epidemiological characteristics and prediction model construction of hand, foot and mouth disease in Quzhou City, China, 2005-2023.
Front Public Health
January 2025
Department of Immunity, Quzhou Center for Disease Control and Prevention, Quzhou, Zhejiang, China.
Background: HFMD is a common infectious disease that is prevalent worldwide. In many provinces in China, there have been outbreaks and epidemics of whooping cough, posing a threat to public health.
Purpose: It is crucial to grasp the epidemiological characteristics of HFMD in Quzhou and establish a prediction model for HFMD to lay the foundation for early warning of HFMD.
Learning the fitness dynamics of pathogens from phylogenies.
Nature
January 2025
Department of Genetics, University of Cambridge, Cambridge, UK.
The dynamics of the genetic diversity of pathogens, including the emergence of lineages with increased fitness, is a foundational concept of disease ecology with key public-health implications. However, the identification of such lineages and estimation of associated fitness remain challenging, and is rarely done outside densely sampled systems. Here we present phylowave, a scalable approach that summarizes changes in population composition in phylogenetic trees, enabling the automatic detection of lineages based on shared fitness and evolutionary relationships.
View Article and Find Full Text PDFReal-Life Insights into Pertussis Diagnosis: High Yield of PCR Testing and Clinical Outcomes-An Emerging Old Enemy or Just a Sign of PCR Times?
J Pers Med
November 2024
Department of Respiratory Medicine, Faculty of Medicine, University of Thessaly, Biopolis, 41500 Larissa, Greece.
Pertussis remains a significant public health concern despite effective vaccines due to diagnostic challenges and symptom overlap with other respiratory infections. This study assesses the prevalence of using advanced polymerase chain reaction (PCR) testing and examines the clinical outcomes over a one-month follow-up. We conducted a cross-sectional study at the University Hospital of Larissa, Greece, from April to June 2024, collecting 532 nasopharyngeal swabs from patients with respiratory symptoms.
View Article and Find Full Text PDFGenomic epidemiology and evolution of under the vaccination pressure of acellular vaccines in Beijing, China, 2020-2023.
Emerg Microbes Infect
December 2024
Beijing Chaoyang District Center for Disease Control and Prevention, Beijing 100021, China.
Pertussis (or whooping cough) has experienced a global resurgence despite widespread vaccine efforts. In China, the incidence of pertussis has rapidly increased, particularly following the COVID-19 pandemic. Whole-genome sequencing analysis was performed on 60 strains isolated in Beijing from 2020 to 2023, and the sequences were compared with those of 635 strains from China and 943 strains from other countries.
View Article and Find Full Text PDFDecreased vaccine coverage and waning immunity are cited as factors.
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