AI Article Synopsis
- Pneumonia is a common issue for people who have received solid organ transplants, affecting both their health and the success of the transplant.
- A study analyzed clinical data from nearly 7,500 patients, separating solid organ transplant (SOT) recipients from non-transplant (NT) patients, revealing that SOT recipients tend to be younger, more often male, and have more health complications.
- Findings indicate that SOT recipients face significantly higher mortality rates, especially at the one-year mark, highlighting the need for careful monitoring and follow-up care for these patients.
Article Abstract
Background: Pneumonia is a frequent complication of solid organ transplantation that adversely impacts both graft and recipient survival. There is a paucity of data on community-acquired pneumonia (CAP) in transplant recipients, particularly the long term outcomes. We conducted a study to compare the clinical characteristics and outcomes of pneumonia in solid organ transplant (SOT) recipients to those in non-transplant (NT) recipients.
Material And Methods: Clinical characteristics were abstracted from electronic medical records. Outcomes included time to hospital discharge, short and long-term mortality. Inverse-propensity score weights were assigned to account for between-group differences. Adjusted analysis included a weighted logistic regression. Results were reported as odds ratios with a corresponding 95 % confidence interval (CI).
Results: A total of 7449 patients were admitted with CAP. Patients were divided into two groups: SOT recipients 42 (0.56 %) and NT recipients 7396 (99.2 %). SOT recipients were younger, more commonly males, with higher prevalence of comorbidities. After accounting for inverse-propensity score weighting, the odds of mortality were higher in SOT recipients in hospital, at 30 days and at 1 year. The magnitude of increase in mortality for SOT recipients was greatest at 1 year with 1.41 (95 % CI: 1.38-1.44) times higher odds.
Conclusion: In patients with CAP, SOT recipients are younger, more commonly male and have more co-morbidities compared with NT recipients. They also have higher 1 year mortality after adjustment. Clinicians must be vigilant toward the pronounced long-term mortality risk among these patients and ensure continued follow-up care for them.
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| http://dx.doi.org/10.1016/j.rmed.2024.107698 | DOI Listing |
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