AI Article Synopsis

  • Depression is a common mental health issue, and this research investigates the use of nanotechnology to enhance the delivery and effectiveness of paroxetine hydrochloride, an antidepressant.
  • The study developed liposomes and nanocapsules to carry the drug, with findings showing that the particle size ranged from 121.81 to 310.73 nm and drug release was slower with liposomes compared to nanocapsules.
  • Experimental tests on mice indicated that both nanostructures effectively reduced signs of depression and anxiety, suggesting they could be useful for improving paroxetine's therapeutic effects at lower doses.

Article Abstract

Depression is one of the most common psychiatric disorders. Nanotechnology has emerged to optimize the pharmacological response. Therefore, the aim of this work was to develop and characterize liposomes and nanocapsules containing paroxetine hydrochloride and evaluate their antidepressant-like effect using the open field and tail suspension tests in mice. Liposomes and nanocapsules were prepared using the reverse-phase evaporation and nanoprecipitation methods, respectively. The particle size of the formulation ranged from 121.81 to 310.73 nm, the polydispersity index from 0.096 to 0.303, the zeta potential from -11.94 to -34.50 mV, the pH from 5.31 to 7.38, the drug content from 80.82 to 94.36 %, and the association efficiency was 98 %. Paroxetine hydrochloride showed slower release when associated with liposomes (43.82 %) compared to nanocapsules (95.59 %) after 10 h. In Vero cells, in vitro toxicity showed a concentration-dependent effect for paroxetine hydrochloride nanostructures. Both nanostructures decreased the immobility time in the TST at 2.5 mg/kg without affecting the number of crossings in the open field test, suggesting the antidepressant-like effect of paroxetine. In addition, the nanocapsules decreased the number of groomings, reinforcing the anxiolytic effect of this drug. These results suggest that the nanostructures were effective in preserving the antidepressant-like effect of paroxetine hydrochloride even at low doses.

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Source
http://dx.doi.org/10.1016/j.ijpharm.2024.124304DOI Listing

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