In tissue homeostasis, intestinal stem cells (ISCs) undergo continuous self-renewal to sustain rapid cellular turnover. In this issue of Cell, Capdevila et al. and Malagola, Vasciaveo, et al. identify a new ISC population in the upper crypt that can generate Lgr5 stem cells during homeostasis.
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| http://dx.doi.org/10.1016/j.cell.2024.04.021 | DOI Listing |
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