AI Article Synopsis
- The study investigates the role of circUBE2D2 in promoting ovarian cancer progression by upregulating HMGB1 and inhibiting miR-885-5p.
- Researchers used various assays to assess cell functions, confirming that circUBE2D2 acts as a sponge for miR-885-5p, which directly targets HMGB1.
- Findings suggest that targeting circUBE2D2 may offer a novel treatment approach for ovarian cancer by reducing tumor growth and altering cell behaviors.
Article Abstract
Background: The newly discovered CircUBE2D2 has been shown to abnormally upregulate and promote cancer progression in a variety of cancers. The present study explored circUBE2D2 (hsa_circ_0005728) in Ovarian Cancer (OC) progression.
Methods: CircUBE2D2, miR-885-5p, and HMGB1 were examined by RT-qPCR or WB. SKOV-3 cell functions (including cell viability, apoptosis, migration, and invasion) were validated using the CCK-8, flow cytometry, scratch assay, and transwell assay, respectively. The direct relationship between miR-885-5p and circUBE2D2 or HMGB1 was confirmed by a dual-luciferase reporter and RNA pull-down analysis. circUBE2D2's role in vivo tumor xenograft experiment was further probed.
Results: OC tissue and cell lines had higher circUBE2D2 and HMGB1 and lower miR-885-5p. Mechanically, CircUBE2D2 shared a binding relation with miR-885-5p, while miR-885-5p can directly target HMGB1. Eliminating circUBE2D2 or miR-885-5p induction inhibited OC cell activities. However, these functions were relieved by down-regulating miR-885-5p or HMGB1 induction. Furthermore, circUBE2D2 knockout reduced tumor growth.
Conclusion: CircUBE2D2 regulates the expression of HMGB1 by acting as a sponge of ceRNA as miR-885-5p, thereby promoting the control of OC cell proliferation and migration and inhibiting cell apoptosis. Targeting CircUBE2D2 could serve as a new potential treatment strategy for OC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11214364 | PMC |
| http://dx.doi.org/10.1016/j.clinsp.2024.100391 | DOI Listing |
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Article Synopsis
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