AI Article Synopsis
- New glyco-reagents based on carbonyl sulfoxonium ylides have been created for synthesizing C-glycosides, which are versatile molecules featuring sugar units.
- The synthesis process uses a Ru-catalyzed strategy that involves C-H activation/annulation and can handle various types of sugar donors.
- This advancement allows for more effective stereoselective production of complex heterocyclic C-glycosides and can be applied to large-scale manufacturing or modifications of natural products and pharmaceuticals.
Article Abstract
New carbonyl sulfoxonium ylide glyco-reagents have been developed, enabling the synthesis of versatile heteroarene C-glycosides through a Ru-catalyzed C-H activation/annulation strategy. These reactions tolerate various saccharide donors and represent a significant advance in the stereoselective synthesis of heterocyclic C-glycosides. Furthermore, the strategy and methods could be applied to large-scale reactions and late-stage modifications of some structurally complex natural products or drugs.
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| http://dx.doi.org/10.1021/acs.orglett.4c01287 | DOI Listing |
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