AI Article Synopsis

  • Exercise is beneficial for cancer patients, especially in post-surgery rehabilitation, but there hasn’t been much research specifically on its effects after nephrectomy surgery.
  • An animal model was created to simulate nephrectomy patients with and without exercise, and bioinformatics analysis was performed on lung tissue samples using RNA sequencing data.
  • The analysis revealed that exercise improves immune-related gene expression pathways in nephrectomy models, indicating potential genetic mechanisms behind the positive effects of exercise after surgery.

Article Abstract

Exercise offers numerous benefits to cancer patients and plays an essential role in postsurgical cancer rehabilitation. However, there is a lack of research examining the effects of exercise after the surgical stress of nephrectomy. To address this gap, we created an animal model that simulated patients who had undergone nephrectomy with or without an exercise intervention. Next, we performed a bioinformatic analysis based on the data generated by the RNA sequencing of the lung tissue sample. An overrepresentation analysis was conducted using two genome databases (Gene Ontology and Kyoto Encyclopedia of Genes and Genomes [KEGG]). A KEGG analysis of the exercise-treated nephrectomy mice revealed enrichment in immune-related pathways, particularly in the NF-κB and B cell-related pathways. The expression of CD79A and IGHD, which are responsible for B cell differentiation and proliferation, was upregulated in the nephrectomy mice. Differential gene expression was categorized as significantly upregulated or downregulated according to nephrectomy and exercise groups. Notably, we identified several gene expression reversals in the nephrectomy groups with exercise that were not found in the nephrectomy without exercise or control groups. Our preliminary results potentially reveal a genetic landscape for the underlying mechanisms of the effects of exercise on our nephrectomy model.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11161109PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0303334PLOS

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Article Synopsis
  • Exercise is beneficial for cancer patients, especially in post-surgery rehabilitation, but there hasn’t been much research specifically on its effects after nephrectomy surgery.
  • An animal model was created to simulate nephrectomy patients with and without exercise, and bioinformatics analysis was performed on lung tissue samples using RNA sequencing data.
  • The analysis revealed that exercise improves immune-related gene expression pathways in nephrectomy models, indicating potential genetic mechanisms behind the positive effects of exercise after surgery.
View Article and Find Full Text PDF

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