This essay is dedicated to the memory of my father David Sompolinsky. As a medical student in Veterinary Medicine in Copenhagen, with the support of his professors and the Danish Resistance, David organised the rescue of 700 Danish Jews in October 1943, helping them escape Nazi persecution and find safety in Sweden.
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Anal Bioanal Chem
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Urinary exosome metabolite analysis has demonstrated notable advantages in uncovering disease status, yet its potential in decoding the intricacies of clear cell renal cell carcinoma (ccRCC) remains untapped. To address this, a core-shell magnetic titanium organic framework was designed to capture urinary exosomes and assist laser desorption/ionization mass spectrometry (LDI MS) to decipher the exosomal metabolic profile of ccRCC, with high sensitivity, throughput, and speed. A total of 492 urinary exosome metabolite fingerprints (UEMFs) from 176 samples were extracted for exploring the differences between ccRCC and healthy individuals.
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Consultant (Radiodiagnosis), Medica Super Specialty Hospital, Kolkata, India.
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View Article and Find Full Text PDFInvolvement of CN Sites in Solvothermally Engineered Metal-Free Carbon Material From Weed Lantana camara for the Detection of Mercury Ions: Experimental and DFT Insights.
Luminescence
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Department of Chemistry and Chemical Sciences, Central University of Himachal Pradesh, Kangra, India.
Article Synopsis
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Multilayer Analysis of RNA Sequencing Data in Alzheimer's Disease to Unravel Molecular Mysteries.
Adv Neurobiol
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Department of Bioengineering, Gebze Technical University, Gebze, Kocaeli, Turkey.
Alzheimer's disease (AD) is a complex disease, and numerous cellular events may be involved in etiology. RNAseq-based transcriptome data hold multilayer information content, which could be crucial in unraveling molecular mysteries of AD. It enables quantification of gene expression levels, identification of genomic variants, and elucidation of splicing anomalies such as exon skipping and intron retention.
View Article and Find Full Text PDFThe impact of retrotransposons on zygotic genome activation and the chromatin landscape of early embryos.
Ann N Y Acad Sci
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Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan.
In mammals, fertilization is followed by extensive reprogramming and reorganization of the chromatin accompanying the transcriptional activation of the embryo. This reprogramming results in blastomeres with the ability to give rise to all cell types and a complete organism, including extra-embryonic tissues, and is known as totipotency. Transcriptional activation occurs in a process known as zygotic genome activation (ZGA) and is tightly linked to the expression of transposable elements, including endogenous retroviruses (ERVs) such as endogenous retrovirus with leucine tRNA primer (ERVL).
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