AI Article Synopsis

  • Temporal lobe epilepsy (TLE) is the most common drug-resistant epilepsy, often caused by hippocampal sclerosis (HS), and early surgery can have good results for some patients.
  • Not all people with TLE can have surgery, so other treatments like subiculum stimulation should be considered for them.
  • In one case, a 50-year-old woman with left HS saw a 67% reduction in her seizures after opting for unilateral subiculum stimulation instead of surgery, demonstrating its effectiveness for drug-resistant epilepsy.

Article Abstract

Temporal lobe epilepsy (TLE) is the most common form of drug-resistant epilepsy. The main pathological changes primarily involve hippocampal sclerosis (HS). Early resective surgery of the sclerotic hippocampus is typically associated with favorable clinical outcomes. However, not all patients are suitable candidates for resective surgery of mesial temporal lobe structures. Therefore, alternative treatment modalities should be considered. We present the case of a 50-year-old right-handed woman with left HS who underwent unilateral subiculum stimulation for drug-resistant epilepsy (DRE). Since the age of 10, the patient had been experiencing focal to bilateral tonic-clonic seizures (FBTCS). Despite multiple antiseizure medications, she experienced 12 to 17 FBTCS per month in the last two years. Due to concerns about potential memory decline and personal preferences, she refused resective surgery. As an alternative, the patient underwent left unilateral subiculum stimulation. The stimulation resulted in a nearly 67 % reduction in seizure frequency at the last follow-up (20 months after surgery). This case highlights that drug-resistant epilepsy may be effectively treated with subicular stimulation in patients with HS.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153886PMC
http://dx.doi.org/10.1016/j.ebr.2024.100677DOI Listing

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