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The Association Between the rs2200733 SNP and Atrial Fibrillation Among Arabs: A Study from Jordan.
Biologics
December 2024
Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Introduction: Atrial fibrillation (AFib) is a common disorder featured by an irregular and fast heartbeat. The etiology of AFib is complex and involves genetic and environmental factors. The rs2200733 single nucleotide polymorphism (SNP) is located in close proximity to the promoter of paired-like homeodomain transcription factor 2 (PITX2) which plays a role in heart development.
View Article and Find Full Text PDFα-Synuclein Gene Hypomethylation in LRRK2 Parkinson's Disease Patients.
Mov Disord
December 2024
Laboratory of Parkinson's and Other Movement Disorders, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
Background: α-Synuclein (SNCA) gene hypomethylation was reported in idiopathic Parkinson's disease (iPD). Based on a high clinical resemblance between iPD and leucine-rich repeat kinase 2 (LRRK2)-driven Parkinson's disease (L2PD), we investigated the epigenetic status of SNCA in an extensive LRRK2 clinical cohort from Spain.
Methods: We assessed the methylation levels of 23 CpG sites in the SNCA promoter region using peripheral blood DNA from L2PD patients (n = 151), LRRK2 nonmanifesting carriers (n = 55), iPD patients (n = 115), and healthy control subjects (n = 154) (total: N = 475).
Antibodies to watch in 2025.
MAbs
December 2025
Business Intelligence Research, The Antibody Society, Inc., Framingham, MA, USA.
The commercial development of antibody therapeutics is a global enterprise involving thousands of biopharmaceutical firms and supporting service organizations. To date, their combined efforts have resulted in over 200 marketed antibody therapeutics and a pipeline of nearly 1,400 investigational product candidates that are undergoing evaluation in clinical studies as treatments for a wide variety of diseases. Here, we discuss key events in antibody therapeutics development that occurred during 2024 and forecast key events related to the late-stage clinical pipeline that may occur in 2025.
View Article and Find Full Text PDFA South African View of the New European Society for Vascular Surgery Vascular Trauma Guidelines.
Eur J Vasc Endovasc Surg
December 2024
Wits Donald Gordon Medical Centre, Johannesburg, South Africa.
The New European Society for Vascular Surgery Clinical Practice Guidelines for Managing Vascular Trauma are Fresh, Bold, and Mostly Correct.
Eur J Vasc Endovasc Surg
December 2024
Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle, WA, USA. Electronic address:
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