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| http://dx.doi.org/10.1002/hpja.888 | DOI Listing |
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SARS-CoV-2 Evolution: Implications for Diagnosis, Treatment, Vaccine Effectiveness and Development.
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Microbiology and Virology Unit, Department of Biomedical Sciences, University of Cagliari, University Campus, 09042 Monserrato, Italy.
The COVID-19 pandemic, driven by the rapid evolution of the SARS-CoV-2 virus, presents ongoing challenges to global public health. SARS-CoV-2 is characterized by rapidly evolving mutations, especially in (but not limited to) the spike protein, complicating predictions about its evolutionary trajectory. These mutations have significantly affected transmissibility, immune evasion, and vaccine efficacy, leading to multiple pandemic waves with over half a billion cases and seven million deaths globally.
View Article and Find Full Text PDFCurrent update on the neurological manifestations of long COVID: more questions than answers.
EXCLI J
November 2024
Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.
Since the outbreak of the COVID-19 pandemic, there has been a global surge in patients presenting with prolonged or late-onset debilitating sequelae of SARS-CoV-2 infection, colloquially termed long COVID. This narrative review provides an updated synthesis of the latest evidence on the neurological manifestations of long COVID, discussing its clinical phenotypes, underlying pathophysiology, while also presenting the current state of diagnostic and therapeutic approaches. Approximately one-third of COVID-19 survivors experience prolonged neurological sequelae that persist for at least 12-months post-infection, adversely affecting patients' quality of life.
View Article and Find Full Text PDFHelicobacter pylori and gastric cancer: mechanisms and new perspectives.
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Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Gastric cancer remains a significant global health challenge, with Helicobacter pylori (H. pylori) recognized as a major etiological agent, affecting an estimated 50% of the world's population. There has been a rapidly expanding knowledge of the molecular and pathogenetic mechanisms of H.
View Article and Find Full Text PDFDevelopment of a health equity tool in resuscitation sciences and application to current research in extracorporeal cardiopulmonary resuscitation for cardiac arrest.
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January 2025
Department of Emergency Services, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Division of Emergency Medicine, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Background: Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used for adults with cardiac arrest (CA) refractory to Advanced Cardiovascular Life Support (ACLS). Concerns exist that adding ECPR could worsen health inequities, defined as differences in health outcomes that are unfair or unjust. Current guidelines do not explicitly address this issue.
View Article and Find Full Text PDFCaledonian reactivation and reworking of Timanian thrust systems and implications for latest Mesoproterozoic to mid-Paleozoic tectonics and magmatism in northern Baltica.
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October 2024
Brønnøy Kalk, Velfjord, Nordland, 8960, Norway.
Background: The Trollfjorden-Komagelva Fault Zone is the southernmost thrust fault of the Timanian Orogen and extends for thousands of kilometers from northwestern Russia to northern Norway. Though there is little about its location onshore northeastern Norway, where it is mapped as a major fault system dominantly comprised of NNE-dipping thrust faults, its continuation to the west below Caledonian nappes and offshore post-Caledonian sedimentary basins remains a matter of debate.
Methods: The present study provides a more definitive answer about the continuation of Trollfjorden-Komagelva Fault Zone west of the Varanger Peninsula by using seismic reflection, bathymetric, topographic, and magnetic data onshore Finnmark and offshore on the Finnmark Platform.
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