AI Article Synopsis
- The study investigated the effects of antenatal magnesium sulfate (MgSO) on mortality and the incidence of intraventricular hemorrhage (IVH) in very low birth weight (VLBW) infants born before 32 weeks of gestation.
- Antenatal MgSO was linked to a significantly reduced death rate and a lower combined rate of severe IVH and death, but did not show a significant impact on the incidence of severe IVH alone.
- The findings suggest that administering MgSO during pregnancy could improve survival rates in VLBW infants, although it may not specifically reduce severe IVH rates.
Article Abstract
Objective: To explore the association between antenatal magnesium sulfate (MgSO), mortality and incidence of intraventricular hemorrhage (IVH) in very low birth weight (VLBW) infants.
Study Design: Retrospective, cohort study of infants <32 weeks' GA born at centers of NEOCOSUR Network between January 2015 and December 2020. Subjects were categorized as exposed vs non-exposed to antenatal MgSO. Primary outcomes were death, incidence of severe IVH (Grade III-IV) and severe IVH/death. Secondary outcomes included relevant morbidities.
Results: 7418 VLBW infants were eligible. Antenatal MgSO was associated with a significantly decreased death rate after admission (aOR 0.67 [95% CI, 0.49-0.94]) and severe IVH/ death (aOR 0.68 [95% CI, 0.50-0.93]). No significant reduction in severe IVH was observed (aOR 1.11 [95% CI, 0.72-1.71]). No differences between groups were observed in rates of morbidities.
Conclusion: Antenatal MgSO was associated with a decreased death rate after admission and in severe IVH/ death.
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| http://dx.doi.org/10.1038/s41372-024-02025-y | DOI Listing |
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