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The tip of the iceberg: a plethora of lung nodules in the general population.
Eur Respir J
June 2024
Pulmonary, Critical Care and Sleep Medicine, Mount Sinai Morningside Hospital, Icahn School of Medicine, New York, NY, USA.
Use of Artificial Intelligence in Clinical Neurology.
Semin Neurol
February 2022
Digital Clinical Research Organization, Data Science Office, Mass General Brigham, Boston, Massachusetts.
Artificial intelligence is already innovating in the provision of neurologic care. This review explores key artificial intelligence concepts; their application to neurologic diagnosis, prognosis, and treatment; and challenges that await their broader adoption. The development of new diagnostic biomarkers, individualization of prognostic information, and improved access to treatment are among the plethora of possibilities.
View Article and Find Full Text PDFCo-extinctions annihilate planetary life during extreme environmental change.
Sci Rep
November 2018
ARC Centre of Excellence for Australian Biodiversity and Heritage, Global Ecology, College of Science and Engineering, Flinders University, Adelaide, Australia.
Climate change and human activity are dooming species at an unprecedented rate via a plethora of direct and indirect, often synergic, mechanisms. Among these, primary extinctions driven by environmental change could be just the tip of an enormous extinction iceberg. As our understanding of the importance of ecological interactions in shaping ecosystem identity advances, it is becoming clearer how the disappearance of consumers following the depletion of their resources - a process known as 'co-extinction' - is more likely the major driver of biodiversity loss.
View Article and Find Full Text PDFDrug Development in Endometriosis and Adenomyosis: It Takes More Than Just Good Science.
Reprod Sci
September 2018
2 Shanghai OB/GYN Hospital, Fudan University, Shanghai, China.
The pipelines of pharmaceutical companies are filled with thousands of promising new compounds for a plethora of indications. Yet, a close review of the drugs that have recently been in clinical trials quickly reveals that only a handful of drugs under evaluation in women with endometriosis can be genuinely qualified as truly innovative and breakthrough drugs. Why is there such an industry-wide lukewarm interest in drug research and development for endometriosis/adenomyosis? Why are pharmaceutical companies so reluctant to initiate programs or invest in academic research in endometriosis/adenomyosis? It is evident that a substantial part of the novel druggable targets originate from research in academia.
View Article and Find Full Text PDFPhylogeography of Eomecon chionantha in subtropical China: the dual roles of the Nanling Mountains as a glacial refugium and a dispersal corridor.
BMC Evol Biol
February 2018
Laboratory of Subtropical Biodiversity, Jiangxi Agricultural University, Nanchang, Jiangxi, 330045, China.
Background: Mountains have not only provided refuge for species, but also offered dispersal corridors during the Neogene and Quaternary global climate changes. Compared with a plethora of studies on the refuge role of China's mountain ranges, their dispersal corridor role has received little attention in plant phylogeographic studies. Using phylogeographic data of Eomecon chionantha Hance (Papaveraceae), this study explicitly tested whether the Nanling Mountains, which spans from west to east for more than 1000 km in subtropical China, could have functioned as a dispersal corridor during the late Quaternary in addition to a glacial refugium.
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