Acetylcholinesterase (AChE) inhibitors are still an important option for managing symptoms of mild to moderate Alzheimer's disease. In this study, we aimed to evaluate the potential AChE inhibitory activity of two Argentinian endemic Solanaceae species, and . UHPLC-DAD-HRMS metabolite profiling revealed the presence of withanolides in the active CHCl subextracts. Their fractionation led to the isolation and identification of two known spiranoid withanolides from and three new withanolides with a skeleton similar to that of trechonolide-type withanolides from . The known compounds showed moderate AChE inhibitory activity, while the new ones were inactive.
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