AI Article Synopsis
- The study investigates the genetic links between aggression and alcohol use, specifically focusing on how these genetic factors may influence alcohol-related aggression differently.
- Using polygenic risk scores (PRS) based on genome-wide data, the researchers analyzed the relationship between genetic risks and instances of alcohol-related aggression in two different groups: UCSF Family Alcoholism Study and the National Longitudinal Study of Adolescent to Adult Health.
- Results showed significant links between genetic risks for alcohol use disorder and aggression in the UCSF sample, but not in the Add Health sample, suggesting varying effects based on the context and type of aggression related to alcohol use.
Article Abstract
Objective: A propensity for aggression or alcohol use may be associated with alcohol-related aggression. Previous research has shown genetic overlap between alcohol use and aggression but has not looked at how alcohol-related aggression may be uniquely influenced by genetic risk for aggression or alcohol use. The present study examined the associations of genetic risk for trait aggression, alcohol use, and alcohol use disorder (AUD) with alcohol-related aggression using a polygenic risk score (PRS) approach.
Method: Using genome-wide association study summary statistics, PRSs were created for trait aggression, alcohol consumption, and AUD. These PRSs were used to predict the phenotype of alcohol-related aggression among drinkers in two independent samples: the University of California at San Francisco (UCSF) Family Alcoholism Study ( = 1,162) and the National Longitudinal Study of Adolescent to Adult Health (Add Health; = 4,291).
Results: There were significant associations between the AUD PRS and lifetime alcohol-related aggression in the UCSF study sample. Additionally, the trait aggression PRS was associated with three or more experiences of hitting anyone else and getting into physical fights while under the influence of alcohol, along with a composite score of three or more experiences of alcohol-related aggression, in the UCSF study sample. No significant associations were observed in the Add Health sample. Limited sex-specific genetic effects were observed.
Conclusions: These results provide preliminary evidence that genetic influences underlying alcohol use and aggression are uniquely associated with alcohol-related aggression and suggest that these associations may differ by type and frequency of alcohol-related aggression incidents. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621227 | PMC |
| http://dx.doi.org/10.1037/adb0001015 | DOI Listing |
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