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Clinical characteristics and genome epidemiology of Stenotrophomonas maltophilia in Japan. | LitMetric

AI Article Synopsis

  • Stenotrophomonas maltophilia is a carbapenem-resistant pathogen linked to challenging hospital infections, with a study analyzing its clinical characteristics and genetic makeup across six Japanese hospitals.
  • The study included 78 patients, primarily elderly males with serious comorbidities, showing that those with infections had a notably higher mortality rate compared to those who were merely colonized.
  • While the bacteria predominantly colonized the respiratory tract, infection cases, particularly bacteraemia, led to higher mortality rates; sulfamethoxazole/trimethoprim was found to be the most effective antibiotic against it.

Article Abstract

Background: Stenotrophomonas maltophilia is a carbapenem-resistant Gram-negative pathogen increasingly responsible for difficult-to-treat nosocomial infections.

Objectives: To describe the contemporary clinical characteristics and genome epidemiology of patients colonized or infected by S. maltophilia in a multicentre, prospective cohort.

Methods: All patients with a clinical culture growing S. maltophilia were enrolled at six tertiary hospitals across Japan between April 2019 and March 2022. The clinical characteristics, outcomes, antimicrobial susceptibility and genomic epidemiology of cases with S. maltophilia were investigated.

Results: In total, 78 patients were included representing 34 infection and 44 colonization cases. The median age was 72.5 years (IQR, 61-78), and males accounted for 53 cases (68%). The most common comorbidity was localized solid malignancy (39%). Nearly half of the patients (44%) were immunosuppressed, with antineoplastic chemotherapy accounting for 31%. The respiratory tract was the most common site of colonization (86%), whereas bacteraemia accounted for most infection cases (56%). The 30 day all-cause mortality rate was 21%, which was significantly higher in infection cases than colonization cases (35% versus 9%; adjusted HR, 3.81; 95% CI, 1.22-11.96). Susceptibility rates to ceftazidime, levofloxacin, minocycline and sulfamethoxazole/trimethoprim were 14%, 65%, 87% and 100%, respectively. The percentage of infection ranged from 13% in the unclassified group to 86% in genomic group 6A. The percentage of non-susceptibility to ceftazidime ranged from 33% in genomic group C to 100% in genomic groups 6 and 7 and genomic group geniculate.

Conclusions: In this contemporary multicentre cohort, S. maltophilia primarily colonized the respiratory tract, whereas patients with bacteraemia had the highest the mortality from this pathogen. Sulfamethoxazole/trimethoprim remained consistently active, but susceptibility to levofloxacin was relatively low. The proportions of cases representing infection and susceptibility to ceftazidime differed significantly based on genomic groups.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290880PMC
http://dx.doi.org/10.1093/jac/dkae168DOI Listing

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