Correlation of Noninvasive Cardiac MRI Measures of Left Ventricular Myocardial Function and Invasive Pressure-Volume Parameters in a Porcine Ischemia-Reperfusion Model.

Tejas Deshmukh Dinesh Selvakumar Sujitha Thavapalachandran Oliver Archer Gemma A Figtree Michael Feneley Stuart M Grieve Liza Thomas Faraz Pathan James J H Chong

Radiol Cardiothorac Imaging

From the Centre for Heart Research, Westmead Institute for Medical Research, 176 Hawkesbury Rd, Westmead, Sydney, NSW 2145, Australia (T.D., D.S., S.T., J.J.H.C.); Department of Cardiology, Westmead Hospital, Westmead, Australia (T.D., D.S., S.T., O.A., L.T., J.J.H.C.); Sydney School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia (T.D., D.S., S.T., L.T., J.J.H.C.); Cardiovascular Discovery Group, Kolling Institute, University of Sydney and Royal North Shore Hospital, St Leonards, Sydney, Australia (G.A.F.); Department of Cardiology, St Vincent's Hospital, Darlinghurst, Australia (M.F.); Cardiac Mechanics Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, Australia (M.F.); Imaging and Phenotyping Laboratory, Faculty of Medicine and Health, Charles Perkins Centre, University of Sydney, Sydney, Australia (S.M.G.); Department of Radiology, Royal Prince Alfred Hospital, Camperdown, Australia (S.M.G.); Nepean Clinical School of Medicine, Charles Perkin Centre Nepean, University of Sydney, Kingswood, Australia (F.P.); and Department of Cardiology, Nepean Hospital, Kingswood, Australia (F.P.).

Published: June 2024

Purpose To assess the correlation between noninvasive cardiac MRI-derived parameters with pressure-volume (PV) loop data and evaluate changes in left ventricular function after myocardial infarction (MI). Materials and Methods Sixteen adult female swine were induced with MI, with six swine used as controls and 10 receiving platelet-derived growth factor-AB (PDGF-AB). Load-independent measures of cardiac function, including slopes of end-systolic pressure-volume relationship (ESPVR) and preload recruitable stroke work (PRSW), were obtained on day 28 after MI. Cardiac MRI was performed on day 2 and day 28 after infarct. Global longitudinal strain (GLS) and global circumferential strain (GCS) were measured. Ventriculo-arterial coupling (VAC) was derived from PV loop and cardiac MRI data. Pearson correlation analysis was performed. Results GCS ( = 0.60, = .01), left ventricular ejection fraction (LVEF) ( = 0.60, = .01), and cardiac MRI-derived VAC ( = 0.61, = .01) had a significant linear relationship with ESPVR. GCS ( = 0.75, < .001) had the strongest significant linear relationship with PRSW, followed by LVEF ( = 0.67, = .005) and cardiac MRI-derived VAC ( = 0.60, = .01). GLS was not significantly correlated with ESPVR or PRSW. There was a linear correlation ( = 0.82, < .001) between VAC derived from cardiac MRI and from PV loop data. GCS (-3.5% ± 2.3 vs 0.5% ± 1.4, = .007) and cardiac MRI-derived VAC (-0.6 ± 0.6 vs 0.3 ± 0.3, = .001) significantly improved in the animals treated with PDGF-AB 28 days after MI compared with controls. Conclusion Cardiac MRI-derived parameters of MI correlated with invasive PV measures, with GCS showing the strongest correlation. Cardiac MRI-derived measures also demonstrated utility in assessing therapeutic benefit using PDGF-AB. Cardiac MRI, Myocardial Infarction, Pressure Volume Loop, Strain Imaging, Ventriculo-arterial Coupling © RSNA, 2024.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211950	PMC
http://dx.doi.org/10.1148/ryct.230252	DOI Listing

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