AI Article Synopsis
- PIM kinases (PIM-1, PIM-2, PIM-3) are important for cell survival and proliferation, and their over-expression is linked to various blood cancers, suggesting they could be effective biomarkers and treatment targets in personalized cancer therapies.
- Recent research emphasizes the development of specific inhibitors for these kinases, which have shown positive effects in patients with advanced and hard-to-treat cancers.
- A review of literature from 2016 to the present covers the role of PIM kinases in cancer development as well as detailed insights into the pharmacology and structure of newly patented inhibitors, highlighting their potential for cancer treatment.
Article Abstract
Introduction: PIM Kinases (PIM-1, PIM-2, and PIM-3) have been reported to play crucial role in signaling cascades that govern cell survival, proliferation, and differentiation. Over-expression of these kinases leads to hematological malignancies such as diffuse large B cell lymphomas (DLBCL), multiple myeloma, leukemia, lymphoma and prostate cancer etc. PIM kinases as biomarkers and potential therapeutic targets have shown promise toward precision cancer therapy. The selective PIM-1, PIM-2, and/or PIM-3 isoform inhibitors have shown significant results in patients with advanced stages of cancer including relapsed/refractory cancer.
Areas Covered: A comprehensive literature review of PIM Kinases (PIM-1, PIM-2, and PIM-3) in oncogenesis, the patented PIM kinase inhibitors (2016-Present), and their pharmacological and structural insights have been highlighted.
Expert Opinion: Recently, PIM kinases viz. PIM-1, PIM-2, and PIM-3 (members of the serine/threonine protein kinase family) as therapeutic targets have attracted considerable interest in oncology especially in hematological malignancies. The patented PIM kinase inhibitors comprised of heterocyclic (fused)ring structure(s) like indole, pyridine, pyrazine, pyrazole, pyridazine, piperazine, thiazole, oxadiazole, quinoline, triazolo-pyridine, pyrazolo-pyridine, imidazo-pyridazine, oxadiazole-thione, pyrazolo-pyrimidine, triazolo-pyridazine, imidazo-pyridazine, pyrazolo-quinazoline and pyrazolo-pyridine etc. showed promising results in cancer chemotherapy.
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| http://dx.doi.org/10.1080/13543776.2024.2365411 | DOI Listing |
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