Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11150950 | PMC |
| http://dx.doi.org/10.1016/j.jobcr.2024.03.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Innovations in Drug Delivery Systems for Biologics: Enhancing Stability and Targeted Delivery for Next-Generation Therapeutics.
Zhongguo Ying Yong Sheng Li Xue Za Zhi
January 2025
Department of Life Science, SSSUHE, Kalaburagi, Karnataka, India.
The aim of this study is to explore and evaluate recent innovations in drug delivery systems (DDS) for biologics, focusing on enhancing stability and targeted delivery to improve the efficacy and safety of next-generation therapeutics. The most recent developments in a variety of DDS, such as nanoparticles, microneedles, hydrogels, and biodegradable polymers, were examined in depth. Information from peer-audited diaries, clinical preliminaries, and mechanical reports were blended to survey the presentation of these frameworks concerning dependability, designated conveyance, patient consistence, and controlled discharge.
View Article and Find Full Text PDFA Comprehensive Review on Current Knowledge and Future Potential of Topical Therapies in Breast Cancer Treatment.
Eur J Breast Health
January 2025
Department of Pharmaceutics, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.
Breast cancer remains one of the most prevalent malignancies among women globally. Despite advances in therapeutic options, the prognosis often remains challenging. Breast cancer typically originates in the epithelial lining of glandular tissue ducts (85%) or lobules (15%).
View Article and Find Full Text PDFSelf-Delivering RNAi Compounds for Reduction of Hyperpigmentation.
Clin Cosmet Investig Dermatol
December 2024
Phio Pharmaceuticals, Marlborough, MA, USA.
Purpose: Abnormal melanin synthesis causes hyperpigmentation disorders like melasma and lentigines, impacting psychological well-being. RNA interference (RNAi) uses small RNA molecules to inhibit gene expression by targeting specific mRNA, silencing genes involved in undesirable cellular functions. This study assessed INTASYL compounds, self-delivering RNAi molecules, designed to target and reduce tyrosinase gene expression to decrease pigmentation.
View Article and Find Full Text PDFChlorhexidine-loaded microneedles for treatment of oral diseases.
Int J Pharm
December 2024
Department of Pharmaceutical Engineering, Azrieli College of Engineering Jerusalem, Jerusalem 9103501, Israel. Electronic address:
Chlorhexidine (CHX) is a gold standard therapeutic agent against clinical oral pathogens. However, its oral use is limited due to unpleasant taste, alteration in taste buds, staining of teeth and mucous membranes. Therefore, CHX-loaded PLGA microneedles (MNs) were fabricated for local and controlled release in the oral cavity, using a casting mold method.
View Article and Find Full Text PDFCarvacrol/cyclodextrin/ceria nanoparticle/hyaluronate hybrid microneedle for promoted diabetic wound healing through the modulation of microenvironment.
Int J Biol Macromol
December 2024
School of Biomedical Engineering and Medical Imaging, Army Medical University, Chongqing 400038, China. Electronic address:
Article Synopsis
- Delayed healing in diabetic wounds is primarily due to a dysfunctional microenvironment caused by high blood sugar and ongoing inflammation.
- Topical microenvironment modulation, particularly using microneedles, offers a promising solution to enhance healing by delivering therapeutic agents directly to the wound's surface.
- A hybrid microneedle has been developed incorporating carvacrol, cyclodextrin, mesoporous ceria nanoparticles, and hyaluronate, which improves healing by providing antibacterial, antioxidant, and anti-inflammatory effects to accelerate tissue reconstruction processes like cell proliferation and angiogenesis.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!