AI Article Synopsis
- - This study investigates how eugenol affects the activity of four specific liver enzymes (CYP1A2, CYP2C9, CYP2D6, and CYP3A4) by using human liver microsomes and observing how eugenol inhibits metabolite formation.
- - Eugenol inhibited the activities of CYP1A2 and CYP2C9 significantly more at higher concentrations, with inhibition rates reaching up to about 63% and 67% respectively, while CYP2D6 and CYP3A4 were also affected but to slightly lesser degrees.
- - The findings suggest the potential for herb-drug interactions when eugenol is taken with medications processed by these enzymes, especially CYP2C9, CYP
Article Abstract
This study aimed to provide an understanding of the influence of eugenol on CYP1A2, 2C9, 2D6, and 3A4 in human liver microsomes (HLM). Specific substrate for CYP1A2, 2C9, 2D6, and 3A4 were incubated in HLM with or without eugenol. The formation of their respective metabolites was assessed with HPLC analytical methods. Eugenol at 1, 10 and 100 µM levels inhibited the activity of CYP1A2 and CYP2C9 by 23.38 %, 23.57 %, 39.80 % and 62.82 %, 63.27 %, 67.70 % respectively. While, CYP2D6 and CYP3A4 activity was decreased by 40.70 %, 45.88 %, 62.68 % and 37.41 %, 42.58 % and 67.86 % at 1, 10 and 100 µM eugenol level respectively. The IC value of eugenol for CYP2D6 and CYP3A4 was calculated as 11.09 ± 3.49 µM and 13.48 ± 3.86 µM respectively. Potential herb-drug interactions was noted when eugenol is administered simultaneously with medications metabolized by these enzymes, most notably CYP2C9, CYP2D6 and CYP3A4.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11152732 | PMC |
| http://dx.doi.org/10.1016/j.jsps.2024.102118 | DOI Listing |
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