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http://dx.doi.org/10.1016/j.hroo.2024.03.009 | DOI Listing |
Curr Res Physiol
December 2024
Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Aging is accompanied by a decline in muscle mass, strength, and physical function, a condition known as sarcopenia. Muscle disuse attributed to decreased physical activity, hospitalization, or illness (e.g.
View Article and Find Full Text PDFMessenger RNA (mRNA) translational control plays a pivotal role in regulating cellular proteostasis under physiological and pathological conditions. Dysregulated mRNA translation is pervasive in cancer, in which protein synthesis is elevated to support accelerated cell growth and proliferation. Consequently, targeting the mRNA translation machinery has emerged as a therapeutic strategy to treat cancer.
View Article and Find Full Text PDFMed Biol Eng Comput
January 2025
IDLab, Ghent University-Imec, Technologiepark-Zwijnaarde 126, Zwijnaarde, Belgium.
Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide and greatly reduces the quality of life. Utilizing remote monitoring has been shown to improve quality of life and reduce exacerbations, but remains an ongoing area of research. We introduce a novel method for estimating changes in ease of breathing for COPD patients, using obstructed breathing data collected via wearables.
View Article and Find Full Text PDFSci Rep
January 2025
Computational Fluid Dynamics Laboratory, School of Mechanical Engineering, VIT, Vellore, 632014, India.
Stenosis causes the narrowing of arteries due to plaque buildup, which impedes blood flow and affects flow dynamics. This work numerically analyzes flow fluctuations in stenosed arteries under realistic physiological conditions (resting and exercise) and external body acceleration. The artery is inclined at angle , and blood rheology is modeled using a generalized power-law fluid.
View Article and Find Full Text PDFAppl Physiol Nutr Metab
January 2025
Coventry University, Centre for Sport Exercise and Life Sciences, Coventry, Warwickshire, United Kingdom of Great Britain and Northern Ireland;
Exercise and passive heating share some acute physiological responses. These include increases in body temperature, sweat rate, blood flow, heart rate, and redistribution of plasma and blood volume. These responses can vary depending on the heating modality or dose (e.
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