Background: This study examines the association between the coefficient of variation (%CV) of lithium levels and episode risk and frequency in bipolar patients maintaining serum lithium levels within the therapeutic range.
Methods: We retrospectively reviewed patients with bipolar disorder under care from 2018 to 2022. Inclusion criteria were at least 2 years of follow-up, a minimum of three annual lithium level measurements within the therapeutic range. Patients were categorized based on seizure status. We calculated mean lithium levels, standard deviation (SD), and %CV.
Results: The study included 75 patients (patients with-without episodes, 39-36). Demographic data revealed no significant differences. While mean lithium levels showed no significant disparity between groups, SD and %CV were notably higher in patients with episodes ( < .05). ROC analysis demonstrated AUC values of 0.722 (95% CI: 0.607-0.836 = .001) for %CV and 0.709 (95% CI: 0.593-0.826; = .002) for SD. The optimal %CV cutoff was 17.39, with 67% sensitivity and 69% specificity. A weak correlation was found between %CV and the number of episodes ( = .001, r = 0.376). The post-hoc power analysis for this study was 0.78.
Conclusions: Despite acceptable lithium levels, patients with recent episodes exhibited significant lithium level fluctuations. Integrating %CV with real-time lithium measurements during bipolar disorder follow-up may enhance clinical monitoring and seizure prediction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/00045632241262873 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lithium-doped calcium silicate cement regulates the immune microenvironment and promotes M2 macrophage polarization for enhancing bone regeneration.
J Biol Eng
January 2025
Department of Biomedical Engineering, China Medical University, Taichung, 406040, Taiwan.
Bone defects present a significant challenge in orthopedics and trauma surgery, necessitating innovative approaches to stimulate effective bone regeneration. This study investigated the potential of lithium-doped calcium silicate (LiCS) cement to enhance bone regeneration and modulate the immune microenvironment to promote tissue repair. We synthesized a LiCS ceramic powder and performed comprehensive analyses of its physicochemical properties, including phase composition, morphology, setting time, and mechanical strength.
View Article and Find Full Text PDFUltrafast Lithium-Ion Transport Engineered by Nanoconfinement Effect.
Adv Mater
January 2025
School of Materials Science and Engineering, Beihang University, Beijing, 100191, China.
Amid the burgeoning demand for electrochemical energy storage and neuromorphic computing, fast ion transport behavior has attracted widespread attention at both fundamental and practical levels. Here, based on the nanoconfined channel of graphene oxide laminar membranes (GOLMs), the lithium ionic conductivity typically exceeding 10 mS cm is realized, one to three orders of magnitude higher than traditional liquid or solid lithium-ion electrolyte. Specifically, the nanoconfined lithium hexafluorophosphate (LiPF)-ethylene carbonate (EC)/ dimethyl carbonate (DMC) electrolyte demonstrates the ionic conductivity of 170 mS cm, outperforming the bulk counterpart by ≈16 fold.
View Article and Find Full Text PDFIncorporation of High-Entropy Doped Microregions into 5 V Spinel Oxide for Ultra-Long Cycling Lifespan.
ACS Appl Mater Interfaces
January 2025
Wuhan National Laboratory for Optoelectronics, School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China.
As a leading candidate for high-voltage, cobalt-free cathodes, spinel LiNiMnO (LNMO) oxide is highly attractive for next-generation lithium-ion batteries. However, the instability of cation-oxygen bonds (especially Mn-O) and the adverse two-phase transition of LNMO result in rapid crystal collapse during cycling, thus limiting its practical deployment. To address these issues, herein we exploit the differences in miscibility between dopants and the spinel matrix to embed high-entropy doped microregions (HEDRs, 5-15 nm in size) within the spinel.
View Article and Find Full Text PDFBipolar disorder in patients with psoriasis, and the impact of lithium therapy on psoriasis.
Clin Dermatol
January 2025
Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, RI, USA; GK Dermatology PC, South Weymouth, MA, USA. Electronic address:
There is a significant amount of research examining the link between psoriasis and common mental health disorders; however, studies on less common psychiatric disorders, such as bipolar disorder (BD), remain limited. We conducted a systematic review of studies in the PubMed and Cochrane databases that explored the relationship between BD and psoriasis. Additionally, we evaluated the impact of lithium on psoriasis in patients with BD and included a quality assessment of all the studies.
View Article and Find Full Text PDFLithium restores nuclear REST and Mitigates oxidative stress in down syndrome iPSC-Derived neurons.
Neuroscience
January 2025
Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia; Malaysian Research Institute on Ageing (MyAgeing(TM)), Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia. Electronic address:
Down syndrome (DS), caused by trisomy 21, is characterized by intellectual disability and accelerated aging, with chronic oxidative stress contributing to neurological deficits. REST (Repressor Element-1 Silencing Transcription factor), a crucial regulator of neuronal gene expression implicated in DS neuropathology. This study investigates the neuroprotective potential of lithium, a mood stabilizer with known cognitive-enhancing effects, in restoring levels of REST.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!