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Myelin plasticity in the ventral tegmental area is required for opioid reward. | LitMetric

AI Article Synopsis

  • - All drugs of abuse cause lasting changes in brain circuits that lead to substance-use disorders, and recent research highlights the importance of myelin changes in regulating how these circuits function.! - The study shows that myelin plasticity in the dopaminergic system is crucial for modulating the brain's reward pathways and how we learn about rewards, particularly in relation to opioids.! - Disrupting the formation of oligodendrocytes (cells responsible for myelin) reduces dopamine release and affects how well subjects can learn to associate morphine with a reward, emphasizing the role of myelin in reward learning.

Article Abstract

All drugs of abuse induce long-lasting changes in synaptic transmission and neural circuit function that underlie substance-use disorders. Another recently appreciated mechanism of neural circuit plasticity is mediated through activity-regulated changes in myelin that can tune circuit function and influence cognitive behaviour. Here we explore the role of myelin plasticity in dopaminergic circuitry and reward learning. We demonstrate that dopaminergic neuronal activity-regulated myelin plasticity is a key modulator of dopaminergic circuit function and opioid reward. Oligodendroglial lineage cells respond to dopaminergic neuronal activity evoked by optogenetic stimulation of dopaminergic neurons, optogenetic inhibition of GABAergic neurons, or administration of morphine. These oligodendroglial changes are evident selectively within the ventral tegmental area but not along the axonal projections in the medial forebrain bundle nor within the target nucleus accumbens. Genetic blockade of oligodendrogenesis dampens dopamine release dynamics in nucleus accumbens and impairs behavioural conditioning to morphine. Taken together, these findings underscore a critical role for oligodendrogenesis in reward learning and identify dopaminergic neuronal activity-regulated myelin plasticity as an important circuit modification that is required for opioid reward.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11186775PMC
http://dx.doi.org/10.1038/s41586-024-07525-7DOI Listing

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