AI Article Synopsis

  • Advanced methods like REACT integrate fMRI with the brain's receptor landscape, offering new insights into the brain's multi-scale organization.
  • Normative modeling enables neuroscience to assess individual health deviations instead of just group averages, enhancing our understanding of mental disorders.
  • This study combines these methods to analyze functional networks related to neurotransmitter systems in patients with schizophrenia, bipolar disorder, and ADHD, revealing overlapping symptoms and potential biomarkers for more targeted treatments.

Article Abstract

Advanced methods such as REACT have allowed the integration of fMRI with the brain's receptor landscape, providing novel insights transcending the multiscale organisation of the brain. Similarly, normative modelling has allowed translational neuroscience to move beyond group-average differences and characterise deviations from health at an individual level. Here, we bring these methods together for the first time. We used REACT to create functional networks enriched with the main modulatory, inhibitory, and excitatory neurotransmitter systems and generated normative models of these networks to capture functional connectivity deviations in patients with schizophrenia, bipolar disorder (BPD), and ADHD. Substantial overlap was seen in symptomatology and deviations from normality across groups, but these could be mapped into a common space linking constellations of symptoms through to underlying neurobiology transdiagnostically. This work provides impetus for developing novel biomarkers that characterise molecular- and systems-level dysfunction at the individual level, facilitating the transition towards mechanistically targeted treatments.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153627PMC
http://dx.doi.org/10.1038/s42003-024-06391-3DOI Listing

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