Advanced methods such as REACT have allowed the integration of fMRI with the brain's receptor landscape, providing novel insights transcending the multiscale organisation of the brain. Similarly, normative modelling has allowed translational neuroscience to move beyond group-average differences and characterise deviations from health at an individual level. Here, we bring these methods together for the first time. We used REACT to create functional networks enriched with the main modulatory, inhibitory, and excitatory neurotransmitter systems and generated normative models of these networks to capture functional connectivity deviations in patients with schizophrenia, bipolar disorder (BPD), and ADHD. Substantial overlap was seen in symptomatology and deviations from normality across groups, but these could be mapped into a common space linking constellations of symptoms through to underlying neurobiology transdiagnostically. This work provides impetus for developing novel biomarkers that characterise molecular- and systems-level dysfunction at the individual level, facilitating the transition towards mechanistically targeted treatments.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153627 | PMC |
http://dx.doi.org/10.1038/s42003-024-06391-3 | DOI Listing |
J Clin Med
January 2025
School of Population Health, Curtin University, Perth, WA 6102, Australia.
: The Emotion Regulation Questionnaire (ERQ) is a 10-item self-report measure of two emotion regulation strategies, cognitive reappraisal (CR) and expressive suppression (ES). This study aimed to (1) examine the latent structure of the Polish version of the ERQ, and (2) use it to explore different profiles of emotion regulation strategy use and their links with mental health outcomes. : Our sample was 1197 Polish-speaking adults from the general community in Poland.
View Article and Find Full Text PDFFoods
January 2025
Management College, Ocean University of China, Qingdao 266100, China.
Avoiding food waste has become an important global issue. Given the global impact of food waste and the profound influence of Generation Z on future development, it is crucial to guide them in cultivating awareness and behaviors to reduce food waste, thereby promoting sustainable development. Considering young consumers' specific characteristics and consumption environment, this study extended the Theory of Planned Behavior (TPB) framework by adding two constructs of moral self-identity and scarcity mindset.
View Article and Find Full Text PDFFoods
January 2025
Department of Health Industry Technology Management, Chung Shan Medical University, Taichung 40201, Taiwan.
The increasing popularity of social media and the growth of gourmet food culture have elevated molecular gastronomy as a unique dining experience that enhances consumers' perceptions of value through innovative food presentation and sensory marketing strategies. This study investigates consumer acceptance of molecular gastronomy by utilizing the value-attitude-behavior (VAB) model and the Theory of Planned Behavior (TPB). We examine the interplay between utilitarian and hedonic values, product innovation, and sensory stimulation to understand consumer reactions and attitudes toward molecular gastronomy.
View Article and Find Full Text PDFRes Involv Engagem
January 2025
Department of Experimental Psychology, University of Oxford, Oxford, UK.
Programmes designed to support children with known, or increased likelihood of, autism or ADHD often focus on reducing behaviours central to a clinical diagnosis. However, supporting children to pursue their own goals and cope with everyday life through fostering executive function (EF) development, without enforcing neuro-normative assumptions, may be more acceptable to neurodivergent people, and more beneficial. The co-production process for this neurodiversity-affirming programme involved: Review of research priorities identified during published public-and-clinician consultations; iterative programme development through two pilot rounds with a general community sample; and consultation with stakeholders (parents with a connection to autism or ADHD, alongside early years specialists, psychologists and therapists) to check acceptability of the proposal, and refine the logic model and materials.
View Article and Find Full Text PDFCardiovasc Diabetol
January 2025
Department of Nephrology, The Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun, 130041, Jilin Province, China.
Background: The Cardiovascular-kidney-metabolic (CKM) syndrome, a concept recently proposed by the American Heart Association (AHA), highlights the intricate connection between metabolic, renal, and cardiovascular illnesses. Furthermore, the Atherogenic Index of Plasma (AIP), a useful biomarker for evaluating the risk of Cardiovascular Diseases (CVDs), has been associated with the risk of Adverse Cardiovascular Events (ACEs). Nonetheless, its precise function in populations in CKM syndrome Stages 0-3 remains unknown.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!