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Article Synopsis
  • - The study investigated the effectiveness of condoliase chemonucleolysis (CC) for patients with lumbar disc herniation (LDH), focusing on identifying factors that predict early pain relief after treatment.
  • - Out of 52 patients, 75% experienced significant leg pain relief just one day post-treatment, while those with a smaller baseline straight leg raising (SLR) angle were more likely to be early responders.
  • - The findings suggest that patients with lower pretreatment SLR angles are more likely to achieve early and sustained relief from leg pain following CC, regardless of the characteristics of their disc herniation.
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Introduction: Condoliase-based chemonucleolysis is a minimally invasive intermediate treatment option between conservative approaches and surgical interventions for lumbar disk herniation (LDH). In this study, the effects of psychological factors on the clinical outcomes of condoliase therapy for LDH were assessed.

Methods: This study involved patients with LDH who received condoliase injections over a 1-year follow-up period.

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Sciatica due to a lumbar disc herniation is a frequent symptom, between 13% and 40% of the general population will experience an episode of sciatica during their lives. Different techniques exist to treat this condition. Among them the percutaneous intradiscal Discogel®.

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With the advent of new instrumentation and better imaging techniques that allowed less tissue trauma compared with traditional open procedures, while providing adequate or enhanced visualization of the pathologic site and based upon the successful experience of outpatient spine surgery to assist early ambulation, the trend and evolution toward ''minimal access'' or minimally invasive spine surgery began to develop with greater intensity. Many surgical techniques have flourished with the promise of delivering a safe and efficient alternative, including chemonucleolysis, manual percutaneous discectomy (MPD), automated percutaneous lumbar discectomy (APLD), and percutaneous lumbar laser discectomy (PLLD). Unfortunately, most of these techniques have been demonstrated to be inefficient with high complication rates.

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