B7-H3: a robust target for immunotherapy in prostate cancer.

Trends Cancer

Biobizkaia Health Research Institute, Barakaldo, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain; Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. Electronic address:

Published: July 2024

B7-H3, an immune checkpoint glycoprotein, facilitates immune evasion and the promotion of tumors and is highly expressed on the surface of prostate cancer (PCa) cells, which makes it a feasible and robust candidate for immunotherapies against advanced prostate cancer. Here, we summarize and discuss recent findings on the suitability of targeting B7-H3 in PCa treatment.

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Source
http://dx.doi.org/10.1016/j.trecan.2024.05.003DOI Listing

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