Dereplication of Bioactive Saponin Fractions: The Hidden Saponins.

J Agric Food Chem

Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO), Campus de Excelencia Internacional (ceiA3), School of Science, University of Cadiz, C/República Saharaui n° 7, Puerto Real, Cadiz 11510, Spain.

Published: June 2024

The good phytotoxicity and selectivity against weeds versus tomato or cress make saponin-rich fractions from , , , and attractive candidates as bioherbicides. The saponin contents have only previously been reported for , and as a consequence, simultaneous dereplication has been performed on saponin-rich fractions from the other plants by mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. This strategy enables the identification of a total of 26 saponins, 14 of which have been described previously and 12 of which are proposed as new saponins. They include isomers and a new sugar chain with a β-d-apiofuranose unit. The method is corroborated by the isolation of eight dereplicated saponins from .

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191682PMC
http://dx.doi.org/10.1021/acs.jafc.4c02308DOI Listing

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