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| http://dx.doi.org/10.1113/EP091943 | DOI Listing |
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The impact of speculum uses on the incidence of blepharoptosis in patients undergoing phacoemulsification surgery: A prospective analysis.
Indian J Ophthalmol
February 2025
Orbit and Oculoplasty, Aravind Eye Hospital, Thavalakuppam, Pondicherry, India.
Purpose: The primary objective of this study was to investigate the possible role and assess the potential relationship of speculum use during phacoemulsification surgery in the occurrence of blepharoptosis.
Methods: Our study is a prospective observational design to analyze patients who underwent phacoemulsification surgery under topical anesthesia between October 2017 and May 2018 at a tertiary eye hospital in South India. All patients had their Margin Reflex Distance 1 (MRD1), levator palpebrae superioris (LPS) function, and lid crease distance (LCD) measured before and after surgery on day one, one month, three months, and six months to evaluate the extent of ptosis at each time point that was recorded clinically and photographic documentation for accurate evaluation.
GATv2EPI: Predicting Enhancer-Promoter Interactions with a Dynamic Graph Attention Network.
Genes (Basel)
November 2024
Department of Orthopedic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
Background: The enhancer-promoter interaction (EPI) is a critical component of gene regulatory networks, playing a significant role in understanding the complexity of gene expression. Traditional EPI prediction methods focus on one-to-one interactions, neglecting more complex one-to-many and many-to-many patterns. To address this gap, we utilize graph neural networks to comprehensively explore all interaction patterns between enhancers and promoters, capturing complex regulatory relationships for more accurate predictions.
View Article and Find Full Text PDFImpact of Enhanced Recovery After Surgery protocol with multimodal anesthesia on perioperative outcomes after open abdominal aortic aneurysm repair.
J Vasc Surg
December 2024
Department of Surgery, Florida Atlantic University College of Medicine, Boca Raton, FL; Baptist Health South Florida at Boca Raton Regional Hospital, Boca Raton, FL. Electronic address:
Objective: Enhanced Recovery After Surgery (ERAS) clinical pathways have demonstrated improved perioperative outcomes after major surgery. However, its adoption within vascular surgery has been limited. In this study, we examined the impact of an ERAS protocol with multimodal anesthesia on open abdominal aortic aneurysm (AAA) repair by comparing early outcomes before and after its implementation.
View Article and Find Full Text PDFPrevalence of aortoiliac aneurysms in solid organ transplant recipients using the National Inpatient Sample database.
J Vasc Surg
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Division of Vascular Surgery and Endovascular Interventions, Columbia University Irving Medical Center, New York, NY. Electronic address:
Objective: Single-center studies have suggested that solid organ transplant recipients are at increased risk for arterial aneurysms. Moreover, they describe a more aggressive natural history with increased rates of expansion and rupture. In this exploratory analysis, we aimed to assess the frequency of arterial aneurysms in solid organ transplant recipients using a large-scale national database.
View Article and Find Full Text PDFAsymmetrical evolution of promoter methylation of mammalian genes after duplication.
Mol Biol Evol
December 2024
Biology Department, University of Nevada, Reno, Reno, NV, US.
Even though gene duplication is a key source of new genes and evolutionary innovation, it is unclear how duplicates survive the period immediately following gene duplication, in which both copies are functionally redundant. In the absence of epigenetic silencing, the abundance of the gene product would double after gene duplication, which would often have deleterious effects. However, recent duplicates exhibit low expression levels, which could be at least partially explained by high levels of promoter methylation.
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