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The Varying Faces of MOGAD: A Case Series.
Ann Afr Med
November 2024
Department of Neurology, Amala Institute of Medical Sciences, Thrissur, Kerala, India.
Myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG)-associated disease (MOGAD) is an immune mediated demyelinating disorder initially described as a subtype of neuromyelitis optica spectrum disorder with antibodies against MOG. Recently, it has been described as a separate disease entity with unique clinical and radiological features. We herein report the clinical details of eight MOG-IgG-positive patients to highlight the peculiar and varied clinical and radiological features of this condition.
View Article and Find Full Text PDFMyelin oligodendrocyte glycoprotein (MOG) antibody-associated encephalitis induced by Mycoplasma pneumoniae infections.
Ital J Pediatr
September 2024
Department of Pediatric Pulmonology and Immunology, West China Women's and Children's Hospital: Sichuan University West China Second University Hospital, Sichuan Province, Chengdu, China.
Article Synopsis
- This study examines cases of Myelin oligodendrocyte glycoprotein (MOG) antibody-associated encephalitis in children linked to Mycoplasma pneumoniae infections, highlighting the significance of early treatment.
- Three children presented with neurological symptoms and were diagnosed with this condition; they received a combination of immunotherapy and antibiotic treatment.
- The findings suggest that promptly recognizing and treating M. pneumoniae infections can greatly improve recovery outcomes for patients with MOG-IgG-associated encephalitis.
Overlapping syndrome of anti-MOG antibody-associated disease and anti-mGluR5 encephalitis manifested as optic neuritis: A case report.
Medicine (Baltimore)
August 2024
Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan, China.
Rationale: Anti-Myelin oligodendrocyte glycoprotein (MOG) and anti-metabotropic glutamate receptor 5 (mGluR5) double antibody positive encephalitis characterized by optic neuritis is extremely rare. We present a case of overlapping syndrome of MOG-IgG-associated disease and anti-mGluR5 encephalitis manifested as optic neuritis.
Patient Concerns: A 60-year-old Chinses woman presented to the hospital with progressive vision loss and headache for 1 week.
FLAIR Hyperintense Cortical Lesions in a 4-Year-Old Child with Myelin Oligodendrocyte Glycoprotein (MOG)-Associated Encephalitis and Seizures: A Case Report.
Children (Basel)
June 2024
Pediatric Clinic, Department of Medicine and Surgery, Azienda Ospedaliero-Universitaria di Parma, 43126 Parma, Italy.
Article Synopsis
- MOGAD is an uncommon autoimmune disorder affecting the central nervous system, with various symptoms and MRI results, including a rare subtype known as FLAMES, marked by specific MRI findings and seizures.
- This FLAMES subtype exhibits key features like FLAIR hyperintense cortical lesions, headache, and cerebral spinal fluid pleocytosis, which can sometimes resemble other CNS conditions, making diagnosis challenging.
- A case involving a 4-year-old girl with seizures and optic neuritis highlighted the importance of recognizing FLAMES in pediatrics, showing a positive response to steroid treatment with no further neurological issues for a year.
Clinical characteristics, immunological alteration and distinction of MOG-IgG-associated disorders and GFAP-IgG-associated disorders.
J Neuroimmunol
August 2024
Hunan Children's Hospital, China. Electronic address:
Article Synopsis
- The study classified autoimmune encephalitis (AE) based on antibody types, focusing on MOG antibody-associated disease (MOGAD) and GFAP astrocytopathy (GFAP-A), to investigate inflammatory biomarkers in patients versus healthy controls.* -
- Clinical data and samples showed that AE patients had distinct changes in immune markers like cytokines and lymphocyte levels, with different profiles for MOGAD and GFAP-A patients after an 18-month follow-up.* -
- Despite notable differences in inflammatory responses among AE patients, no specific biomarkers were linked to the severity of the disease, suggesting that further investigation is needed in this area.*
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