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Associations of maternal per- and polyfluoroalkyl substance plasma concentrations during pregnancy with offspring polycystic ovary syndrome and related characteristics in project viva.
Environ Res
January 2025
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, USA.
Background: Per- and polyfluoroalkyl substances (PFAS) may impact ovarian folliculogenesis and steroidogenesis, but whether prenatal exposure may impact offspring reproductive health is unknown. This study examines the extent to which maternal PFAS plasma concentrations during pregnancy are associated with polycystic ovary syndrome (PCOS) and related characteristics in female offspring.
Methods: We studied 322 mother-daughter pairs in Project Viva, a Boston-area longitudinal pre-birth cohort enrolled 1999-2002.
[The role of drug Cytoflavin in the correction of dysautonomia in patients with post-COVID syndrome].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
Saint Petersburg State University, St. Petersburg, Russia.
Objective: To evaluate the autonomic dysfunction of cardiovascular system (CVS) in patients with post-COVID syndrome with the help of active orthotest and heart rate variability methods.
Material And Methods: 70 patients with PCOS were examined, who were divided into 2 groups. Group 1 patients received standard therapy and Cytoflavin for 35 days, Group 2 patients received only standard therapy.
International PCOS guideline clinical research priorities roadmap: a co-designed approach aligned with end-user priorities in a neglected women's health condition.
EClinicalMedicine
December 2024
Monash Centre for Health Research and Implementation, Monash University, Melbourne, VIC, Australia.
Article Synopsis
- Polycystic ovary syndrome (PCOS) is a prevalent health issue that can lead to various reproductive, metabolic, and psychological problems, highlighting the need for a collective approach to establish research priorities in this field.
- A comprehensive process involving international surveys, systematic reviews, and peer validation revealed over 150 key research priorities, focusing on diagnosis, care models, patient information, lifestyle management, and fertility treatments for those with PCOS.
- The resulting clinical research roadmap aims to direct future studies according to the needs and interests of women with PCOS and healthcare providers, addressing this commonly overlooked condition.
Functional hypothalamic amenorrhoea and polycystic ovarian morphology: a narrative review about an intriguing association.
Hum Reprod Update
January 2025
Faculty of Medicine Henri Warembourg, University of Lille, Lille, France.
Article Synopsis
- * The article aims to examine how the presence of PCOM affects the diagnosis, treatment, and long-term implications for women with functional hypothalamic amenorrhoea (FHA), indicating that those with FHA and PCOM may have different endocrine and metabolic traits.
- * Research shows that the prevalence of PCOM in women with FHA ranges from 41.9% to 46.7%, indicating a higher rate compared to those without PCOS, which could be
Impact of GnRH antagonist pretreatment on oocyte yield after ovarian stimulation: A retrospective analysis.
PLoS One
October 2024
Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
Article Synopsis
- * Involving 430 women across 860 cycles, the research compares outcomes from a standard stimulation cycle versus one that included early GnRH antagonist pretreatment.
- * Results indicate that the pretreatment significantly increases the total number of retrieved COCs and mature oocytes, suggesting benefits for fertility treatment protocols.
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