Non-clinical, on-demand peer-to-peer (PtP) support apps have become increasingly popular over the past several years. Although not as pervasive as general self-help apps, these PtP support apps are usually free and instantly connect individuals through live texting with a non-clinical volunteer who has been minimally trained to listen and offer support. To date, there is little empirical work that examines whether and how using an on-demand PtP support app improves emotional well-being. Applying regression and multilevel models to = 1000+ PtP conversations, this study examined whether individuals experience emotional improvement following a conversation on a PtP support app (HearMe) and whether dyadic characteristics of the conversation - specifically, verbal and emotional synchrony - are associated with individuals' emotional improvement. We found that individuals reported emotional improvement following a conversation on the PtP support app and that verbal (but not emotional) synchrony was associated with the extent of individuals' emotional improvement. Our results suggest that online PtP support apps are a viable source of help. We discuss cautions and considerations when applying our findings to enhance the delivery of support provision on PtP apps.
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http://dx.doi.org/10.1080/10410236.2024.2360178 | DOI Listing |
Lancet Microbe
December 2024
Amsterdam University Medical Centres, Amsterdam, Netherlands; Department of Global Health and Amsterdam Institute for Global Health and Development, Amsterdam, Netherlands.
Background: Tuberculosis vaccine trials using disease as the primary endpoint are large, time consuming, and expensive. An earlier immunological measure of the protection against disease would accelerate tuberculosis vaccine development. We aimed to assess whether the effectiveness of the Bacillus Calmette-Guérin (BCG) vaccine for prevention of Mycobacterium tuberculosis infection was consistent with that for prevention of tuberculosis disease.
View Article and Find Full Text PDFAm J Respir Crit Care Med
December 2024
Hines VA Hospital, Pulmonary and Critical Care Medicine, Hines, Illinois, United States.
Rationale: No systematic investigation into dyspnea in patients receiving prolonged ventilation (>21 days) after recovering from critical-illness has been published.
Objectives: To determine magnitude, nature and pathophysiological basis of dyspnea during an unassisted-breathing trial in prolonged-ventilation patients.
Methods: Dyspnea intensity and descriptor selection were investigated in 27 prolonged-ventilation patients during a 60-min unassisted-breathing trial.
Chem Sci
November 2024
Iowa State University, Department of Chemistry Ames IA 50011 USA
Supported single-site platinum hydride compounds are promising heterogeneous catalysts for organic transformations. Few methods exist to describe the structures of single-site Pt catalysts with atomic resolution because of their disordered structures and low Pt loadings. Here, we study the compounds formed when bis(tri--butylphosphino)platinum, Pt(P Bu), is supported on dehydroxylated SiO or SiO-AlO.
View Article and Find Full Text PDFBioorg Chem
December 2024
Chemistry Department, V.P. & R.P.T.P. Science College, Mota Bazar Vallabh Vidyanagar, 388120 Anand, Gujarat, India. Electronic address:
Antimicrobial resistance (AMR) is a pressing global health challenge that necessitates the search for novel antimicrobial agents and synthetic methodologies. This study investigates the synthesis and antimicrobial efficacy of 25 novel 1,2,4-triazolo[1,5-a]pyrimidine derivatives, catalyzed by Amla (Phyllanthus emblica) fruit juice, which is rich in organic acids and polyphenolic compounds, thus serving as an environmentally sustainable catalyst, in adherence to green chemistry principles. The synthesis is achieved through a one-pot, solvent-free process that yields high quantities of the desired compounds in significantly less time compared to traditional methods.
View Article and Find Full Text PDFNat Commun
November 2024
Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, B-1070, Brussels, Belgium.
Fat accumulation, de novo lipogenesis, and glycolysis are key drivers of hepatocyte reprogramming and the consequent metabolic dysfunction-associated steatotic liver disease (MASLD). Here we report that obesity leads to dysregulated expression of hepatic protein-tyrosine phosphatases (PTPs). PTPRK was found to be increased in steatotic hepatocytes in both humans and mice, and correlates positively with PPARγ-induced lipogenic signaling.
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