AI Article Synopsis
- Extremely low gestational age newborns (ELGANs) are those born at 28 weeks or earlier and face high risks of preterm birth complications, including infant mortality and neurological issues.
- Despite advancements in care, the rate of preterm births is increasing, and neonatal seizures are a key indicator of potential long-term neurological disorders in these infants.
- The review highlights the need to understand the risk factors associated with neonatal seizures in ELGANs to improve prevention and treatment methods, while also pointing out the limitations of existing studies on the topic.
Article Abstract
Extremely low gestational age newborns (ELGANs) are born at or below 28 weeks of gestational age. Despite improved obstetric care, the incidence of preterm birth continues to rise in advanced countries. Preterm birth remains a major cause of infant mortality, and for infants who survive, neonatal seizures are a significant predictor of later neurologic morbidity. However, little is known about risk factors for neonatal seizures in ELGANs. Understanding the association between neonatal seizures and the development of other neurologic disorders is important given the increasing prevalence of ELGANs. Identifying risk factors that contribute to the development of neonatal seizures in ELGANs may offer insights into novel mechanisms of epileptogenesis in the developing brain and improvements in the prevention or treatment of seizures in preterm infants, including ELGANs. In this literature review, we outline the limitations of epidemiologic studies of neonatal seizures in ELGANs and discuss risk factors for neonatal seizures.
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| http://dx.doi.org/10.1177/08830738241259052 | DOI Listing |
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