AI Article Synopsis
- Salmonella is a significant foodborne pathogen, and with antibiotic use banned in China's egg-laying hens, finding alternatives to reduce S. Typhimurium infections in chickens is crucial for human health.
- A study was conducted on the effects of α-linolenic acid (ALA), an unsaturated fatty acid, demonstrating its ability to protect chickens from S. Typhimurium by reducing intestinal inflammation and modifying gut microbiota.
- The research indicates that adding ALA to chicken feed could be an effective way to enhance resistance against S. Typhimurium infections through improved gut health and intestinal barrier function.
Article Abstract
Salmonella is an important foodborne pathogen. Given the ban on the use of antibiotics during the egg-laying period in China, finding safe and effective alternatives to antibiotics to reduce Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) infections in chickens is essential for the prevention and control of this pathogen and the protection of human health. Numerous studies have shown that unsaturated fatty acids have a positive effect on intestinal inflammation and resistance to infection by intestinal pathogens. Here we investigated the protective effect of α-linolenic acid (ALA) against S. Typhimurium infection in chickens and further explored its mechanism of action. We added different proportions of ALA to the feed and observed the effect of ALA on S. Typhimurium colonization using metagenomic sequencing technology and physiological index measurements. The role of gut flora on S. Typhimurium colonization was subsequently verified by fecal microbiota transplantation (FMT). We found that ALA protects chickens from S. Typhimurium infection by reducing intestinal inflammation through remodeling the gut microbiota, up-regulating the expression of ileocecal barrier-related genes, and maintaining the integrity of the intestinal epithelium. Our data suggest that supplementation of feed with ALA may be an effective strategy to alleviate S. Typhimurium infection in chickens.
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| http://dx.doi.org/10.1016/j.micres.2024.127773 | DOI Listing |
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