An Analgesic Technique for Orogastric Tube Insertion in Newborns: DOLATSONG, a Randomized Multicentric Controlled Trial.

J Perinat Neonatal Nurs

Author Affiliations: Medicine and Neonatal Intensive Care Unit, Centre Hospitalier Sud Francilien, Corbeil Essonnes, France (Mss Darretain and Galand and Drs Granier and Razafimahefa); Medicine and Neonatal Intensive Care Unit, Saint Joseph Hospital, Paris, France (Dr Walter-Nicolet); INSERM, U1153, Epidemiology and Statistics, Sorbonne Paris Cité Research Center, Obstetrical, Perinatal and Pediatric Epidemiology Team, Paris, France (Dr Walter-Nicolet); Medicine and Neonatal Intensive Care Unit, Hôpital Delafontaine, Saint-Denis, France (Drs Harbi and Waszak); SAMU 91, Centre Hospitalier Sud Francilien, Corbeil Essonnes, France (Dr Laborne and Messrs Lagadec and Garrigue); Clinical Research Unit, Centre Hospitalier Sud Francilien, Corbeil Essonnes, France (Dr Laborne and Messrs Lagadec and Garrigue); and CNRD, Hôpital Armand Trousseau (APHP), Paris, France (Dr Maillard).

Published: November 2024

Background: Gastric tube insertion is necessary to support early enteral feeding of newborns during their neonatal intensive care stay. This frequent and invasive procedure is known to be painful. Very few analgesic techniques (sweet solutions, sucking, swaddling, and skin-to-skin contact) are available to reduce the pain caused by orogastric tube insertion procedure. Objective: To determine whether a new orogastric tube insertion technique modifies the pain response in newborns, we hypothesize that inserting an orogastric tube through the nipple of a bottle reduces pain caused by this procedure.

Design: Prospective, controlled, randomized, multicentered and open label study.

Settings: Three neonatal intensive care units in France (2 level 3 units and 1 level 2B).

Participants: Full-term or premature newborns at 32 weeks of gestation or more, postnatal age between 48 hours and 21 days, not ventilated and requiring enteral feeding, were randomized into 2 groups: usual technique ( n = 36) and experimental technique ( n = 35).

Methods: Our experimental technique was to insert the orogastric tube through a modified nipple of a bottle. This method was compared with the usual technique of inserting the tube directly into the newborn's mouth without a support to guide it accompanied by a nipple encouraging sucking with a nonnutritive solution. An association of nonnutritive sucking and orally administered 30% glucose was given to all children for analgesic purposes. Pain during the orogastric tube insertion was assessed on video recordings by 2 independent experts, using a heteroassessment behavioral scale for pain (DAN- Douleur Aiguë du Nouveau-né ; APN-Acute Pain in Newborns). The primary outcome was an Acute Pain in Newborns score of less than 3 at the time of the procedure. Comparisons were made using Fisher exact test or Mann-Whitney U test. Factors associated with an Acute Pain in Newborns score of 3 and greater were explored using univariable and multivariable regression models.

Results: All but 1 video recording in each group were analyzed. Among the 34 neonates in the experimental group, 71.4% (95% CI: [53.7-85.4]) had an Acute Pain in Newborns score of less than 3 during orogastric tube insertion versus 41% (95% CI: [27.9-61.9]) in the control group ( P = .031). Gagging was frequent and nonsignificantly different between the 2 groups (69% in the control group, 51% in the experimental group, P = .13). In multivariable analysis, the experimental technique was an independent factor of pain prevention compared with the usual technique (odds ratio = 0.21 [0.06-0.71], P = .015).

Conclusions: This study suggests that a simple, inexpensive, and feasible technique of orogastric tube insertion through the nipple of a bottle limits pain associated with this procedure in newborns.

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http://dx.doi.org/10.1097/JPN.0000000000000746DOI Listing

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