Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4045/tidsskr.24.0112 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Long-Term Efficacy and Tolerability of an Emollient Containing Glycerol and Paraffin for Moderate-to-Severe Uremic Xerosis: A Randomized Phase 3 Study.
Dermatol Ther (Heidelb)
November 2024
Department of Dermatovenereology, Charles University Third Faculty of Medicine, and Kralovske Vinohrady University Hospital, Prague, Czech Republic.
Article Synopsis
- - The study tested the long-term effectiveness and safety of a topical emollient (V0034CR) for treating uremic xerosis and chronic kidney disease-related itching, comparing it to a vehicle control in a phase 3 trial.
- - Over 28 days, patients applying V0034CR showed a significant improvement in xerosis severity and a greater reduction in scaling compared to those using the control, with 60.2% of the V0034CR group responding positively.
- - While xerosis symptoms returned without treatment after a break, V0034CR helped maintain remission over a longer period, with high patient satisfaction and minimal side effects like minor irritation.
Oxidative stress-induced degradation of Brinzolamide: Isolation and in-depth characterization of unique hydroxylamine and oxime degradation products.
J Pharm Biomed Anal
January 2025
Department of Chemistry, School of Applied Sciences and Humanities, Vignan's Foundation for Science Technology and Research (Deemed to be University), Vadlamudi, Guntur, Andhra Pradesh 522213, India. Electronic address:
Since the safety and efficacy of therapeutic products are strongly related to their stability and purity, impurities including the unavoidable degradation products may affect the pharmacological effect. The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines Q3A requires the identification of process impurities and as well as degradation products in any drug substance to assess the inherent stability of the drug. The present work involves an ICH-guided degradation study for the Brinzolamide (BRZ), a topical ophthalmic drug which is generally used to lower the intraocular pressure (IOP) during glaucoma.
View Article and Find Full Text PDFInnovative UPLC technique for concurrent quantification of etofenamate and benzyl nicotinate in the presence of methylparaben and benzyl alcohol in their topical cream: Greens, white, and Six Sigma methodologies.
Biomed Chromatogr
November 2024
Hikma Pharmaceutical Company, Beni-Suef, 62511, Egypt.
The efficacious treatment of muscle and joint pain relies heavily on etofenamate (ETO) and benzyl nicotinate (BN), which possess robust anti-inflammatory and pain-relieving properties when paired with methylparaben (MP) or benzyl alcohol (BA). In this study, we have established and validated innovative RP-UPLC methods for assessing ETO and BN in the presence of MP or BA in their dosage forms, employing eight green tools to evaluate their eco-friendliness and effectiveness. Reversed phase-ultra-performance liquid chromatography (RP-UPLC) technique employs a flow rate of 0.
View Article and Find Full Text PDFIn vitro permeation testing for the evaluation of drug delivery to the skin.
Eur J Pharm Sci
October 2024
Department of Pharmaceutics, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, United Kingdom. Electronic address:
This review considers the role of in vitro permeation testing (IVPT) for the evaluation of drug delivery from topical formulations applied to the skin. The technique was pioneered by Franz in the 1970's and today remains an important tool in the development, testing and optimization of such topical formulations. An overview of IVPT as well as selection of skin for the experiment, integrity testing of the membrane, and required number of replicate skin samples is discussed.
View Article and Find Full Text PDFThe UPDATE trial (UVB Phototherapy in Dermatology for ATopic Eczema): study protocol for a randomized controlled trial of narrowband UVB with optimal topical therapy versus optimal topical therapy in patients with atopic eczema.
Trials
July 2024
Department of Dermatology, Amsterdam UMC, Location Academic Medical Center, Amsterdam Public Health, Infection and Immunity, University of Amsterdam, Amsterdam, The Netherlands.
Background: Narrowband ultraviolet B (NB-UVB) phototherapy is commonly prescribed for patients with moderate-to-severe atopic eczema (AE). The efficacy of NB-UVB, however, has not yet properly been established, as current evidence is of low certainty. Our aim is to assess the short-term and long-term (cost-)effectiveness and safety of NB-UVB in adult AE patients by performing a pragmatic, multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) trial.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!