Three undescribed compounds including two furosteroid glycosides (perfoloside and 22-O-methylperfoloside) and one stilbenedimer (perfolostilbene) together with 21 known compounds were isolated from the roots of Smilax perfoliata. The structural elucidation was established by extensive uses of HRMS, 1D and 2D spectroscopic techniques. The assignment of the stereocenters in perfolostilbene was based on NOESY data and ECD calculation. Among the isolates, two compounds showed marginal cytotoxic activity against KB and Hela cell lines while seven stilbenoids showed strong to weak antiacetylcholinesterase and antibutyrylcholinesterase activities with IC ranging between 2-197 µM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14786419.2024.2360694 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
SUBSTRATE SPECIFICITY OF Β-GLUCOSIDASE FROM YUCCA GLORIOSA LEAVES.
Georgian Med News
October 2024
European University Tbilisi, Georgia.
Article Synopsis
- Yucca gloriosa leaves have a significant amount of steroid glycosides that undergo transformation from furostanol glycosides to spirostanol glycosides through the enzyme β-glucosidase.
- There are two forms of β-glucosidase: Form I, which can hydrolyze both natural and synthetic substrates, and Form II, which only acts on synthetic substrates.
- Form I shows a higher affinity for natural substrates, indicated by a lower Km value, and both enzyme forms operate best at a temperature of 37°C and a pH of 6.3-6.5.
Furostanol Saponins and Ecdysteroids from Plants of the Genus as Phagostimulants and Predator Deterrents for Larvae of Two Sawfly Species.
Plants (Basel)
August 2024
DO Taxonomy and Phylogeny, Royal Belgian Institute of Natural Sciences, 1000 Brussels, Belgium.
Article Synopsis
- Sawfly species specialized in feeding on Ranunculaceae plants can sequester specific furostanol saponins into their haemolymph, which may help them in defense against predators.
- Research involving various chemical analyses and bioassays indicated that while one species predominantly fed on a non-nutritional stimulant from its host, both species showed differences in response to different plant fractions, with β-sitosterol identified as a nutritional stimulant.
- The study found that the larvae of both sawfly species do not produce ecdysteroids endogenously but accumulate them from their diet, using them effectively as a deterrent against ant predators, especially in the initial days following simulated attacks.
Search for new steroidal glycosides with anti-cancer potential from natural resources.
J Nat Med
September 2024
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo, 192-0392, Japan.
Chemical investigations of higher plants, with particular attention paid to their steroidal glycosides, present a promising approach for generating anti-cancer agents from natural products. We conducted a systematic phytochemical investigation of nine higher plants-whole plants and rhizomes of Convallaria majalis, whole plants of Agave utahensis, roots of Adonis amurensis, seeds of Adonis aestivalis, bulbs of Bessera elegans, bulbs of Fritillaria meleagris, seeds of Digitalis purpurea, underground parts of Yucca glauca, and bulbs of Lilium pumilum-which led to the discovery of novel steroidal glycosides. The structures of these new constituents were determined based on spectroscopic data and chemical transformations.
View Article and Find Full Text PDFFurostanol glycosides, stilbenoids and nucleosides from the roots of , and evaluation of their cytotoxic and anticholinesterase activities.
Nat Prod Res
June 2024
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Hua Mark, Bangkapi, Bangkok, Thailand.
Three undescribed compounds including two furosteroid glycosides (perfoloside and 22-O-methylperfoloside) and one stilbenedimer (perfolostilbene) together with 21 known compounds were isolated from the roots of Smilax perfoliata. The structural elucidation was established by extensive uses of HRMS, 1D and 2D spectroscopic techniques. The assignment of the stereocenters in perfolostilbene was based on NOESY data and ECD calculation.
View Article and Find Full Text PDFFive New Furostanol Glycosides from the Fruits of Tribulus terrestris with NO Production Inhibitory Activity.
Chem Biodivers
September 2024
Department of Chemistry, Vinh University, 182 Le Duan, Ben Thuy, Vinh City, Nghe An, 461010, Vietnam.
Eight furostanol glycosides including five undescribed compounds, named tribufurostanosides A-E (1-5), and three known ones (6-8) were isolated from the fruits of Tribulus terrestris L. Their chemical structures were determined by the IR, HR-ESI-MS, 1D-, and 2D-NMR spectra. Furostanols 1-8 significantly inhibited nitric oxide production in LPS activated RAW 264.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!