The study of the sleep awakening cycle was carried out on implanted cats free of their movements, which received separately each drug in long lasting intake, in order to differentiate their behavioural and electrophysiological activities. The qualitative and quantitative changes induced by these o-anisamides are reported. Like in man, sulpride was found to be quite an original substance. It may be distinguished from the other psychotropic drugs studied because it has no effect on the sleep awakening cycle. The effects of sultopride are comparable with those of some neuroleptics, although its both incisive and sedative activity is very special. The neurophysiological results are discussed in the light of other studies and clinical data.
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