AI Article Synopsis
- Atomic layer deposition (ALD) was used to apply zirconia uniformly on titanium implants in a study assessing its impact on bone integration in rabbits.
- The study involved three groups: control titanium implants, those treated with sandblasting and acid etching, and those coated with zirconia via ALD.
- Results showed that the zirconia-coated implants exhibited significantly better bone-to-implant contact and more mature bone formation around them compared to the control group, indicating enhanced osseointegration.
Article Abstract
Purpose: Atomic layer deposition (ALD) is a method that can deposit zirconia uniformly on an atomic basis. The effect of deposited zirconia on titanium implants using ALD was evaluated in vivo.
Methods: Machined titanium implants (MTIs) were used as the Control. MTIs treated by sandblasting with large grit and acid etching (SA) and MTIs deposited with zirconia using ALD are referred to as Groups S and Z, respectively. Twelve implants were prepared for each group. Six rabbits were used as experimental animals. To evaluate the osteogenesis and osteocyte aspects around the implants, radiological and histological analyses were performed. The bone-to-implant contact (BIC) ratio was measured and statistically analyzed to evaluate the osseointegration capabilities.
Results: In the micro-CT analysis, more radiopaque bone tissues were observed around the implants in Groups S and Z. Histological observation found that Groups S and Z had more and denser mature bone tissues around the implants in the cortical bone area. Many new and mature bone tissues were also observed in the medullary cavity area. For the BIC ratio, Groups S and Z were significantly higher than the Control in the cortical bone area ( < 0.017), but there was no significant difference between Groups S and Z.
Conclusion: MTIs deposited with zirconia using ALD (Group Z) radiologically and histologically showed more mature bone formation and activated osteocytes compared with MTIs (Control). Group Z also had a significantly higher BIC ratio than the Control. Within the limitations of this study, depositing zirconia on the surface of MTIs using ALD can improve osseointegration in vivo.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146613 | PMC |
| http://dx.doi.org/10.2147/IJN.S460392 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Antibacterial and surface properties of post-light-activated metal-free phthalocyanine-deposited TiO nanotube smart surfaces.
Dalton Trans
January 2025
The Department of Chemistry, Karadeniz Technical University, 61080, Trabzon, Turkey.
The utilisation of implantable medical devices has become safer and more prevalent since the establishment of sterilisation methods and techniques a century ago. Nevertheless, device-associated infections remain a significant and growing concern, particularly in light of the continued rise in the number of medical device implantations. This underscores the imperative for the development of efficacious prevention and treatment strategies for device-associated infections, as well as further investigation into the design of innovative antibacterial surfaces for medical device applications.
View Article and Find Full Text PDFBiofabricated tissue model for determining biocompatibility of metallic coatings.
Biomater Sci
January 2025
Biotechnology Centre, The Silesian University of Technology, B. Krzywoustego 8, 44-100, Gliwice, Poland.
Metallic biomaterials are extensively used in orthopedics and dentistry, either as implants or coatings. In both cases, metal ions come into contact with surrounding tissues causing a particular cell response. Here, we present a biofabricated tissue model, consisting of a hydrogel reinforced with a melt electrowritten mesh, to study the effects of bound and released metal ions on surrounding cells embedded in a hydrogel matrix.
View Article and Find Full Text PDFBiomechanical behavior of titanium, cobalt-chromium, zirconia, and PEEK frameworks in implant-supported prostheses: a dynamic finite element analysis.
BMC Oral Health
January 2025
Department of Prosthodontics, Faculty of Dentistry, Hacettepe University, 06230, Sıhhiye/Altındağ, Ankara, Turkey.
Background: The mechanical properties of framework materials significantly influence stress distribution and the long-term success of implant-supported prostheses. Although titanium, cobalt-chromium, zirconia, and polyether ether ketone (PEEK) are widely used, their biomechanical performance under dynamic loading conditions remains insufficiently investigated. This study aimed to evaluate the biomechanical behavior of four framework materials with different Young's modulus using dynamic finite element stress analysis.
View Article and Find Full Text PDFEnhanced porous titanium biofunctionalization based on novel silver nanoparticles and nanohydroxyapatite chitosan coatings.
Int J Biol Macromol
January 2025
Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain. Electronic address:
Titanium is widely used for implants however it presents limitations such as infection risk, stress shielding phenomenon, and poor osseointegration. To address these issues, a novel approach was proposed that involves fabricating porous titanium substrates, to reduce implant stiffness, minimizing stress shielding and bone resorption, and applying polymeric coatings to improve bioactivity. Composite coating prepared from chitosan, silver nanoparticles, and nanohydroxyapatite was optimized to enhance antibacterial properties and promote osseointegration.
View Article and Find Full Text PDFSLA-3D printing and bioactivity enhancement of zirconia anchor screws for temporomandibular joint disc reduction surgery.
J Mech Behav Biomed Mater
January 2025
Center of Stomatological, The Second Hospital, Cheeloo College of Medicine, Shandong University, 250033, PR China; Jinan Key Laboratory of Oral Materials, Jinan, 250033, PR China. Electronic address:
A method is proposed for 3D printing and enhancing the surface bioactivity of zirconia ceramic anchor screws, specifically tailored for temporomandibular joint disc reduction surgery. Initially, the challenge posed by the brittleness and processing difficulties of fine ceramic anchor screws was addressed through the application of SLA-3D printing technology. This allowed for an exploration of the forming accuracy and biomechanical properties of the printed anchor screws.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!