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Resveratrol and piceid enhance efferocytosis by increasing the secretion of MFG-E8 in human THP-1 macrophages. | LitMetric

Resveratrol and piceid enhance efferocytosis by increasing the secretion of MFG-E8 in human THP-1 macrophages.

Biosci Biotechnol Biochem

Department of Food, Life and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, Japan.

Published: August 2024

AI Article Synopsis

  • Efferocytosis, the process where phagocytes clear apoptotic cells, is vital for maintaining body balance and preventing inflammatory diseases like atherosclerosis and autoimmune disorders.
  • The study found that resveratrol and its compound piceid enhance efferocytosis in human macrophages and mouse peritoneal macrophages by increasing the expression and secretion of MFG-E8.
  • Knockdown of MFG-E8 in THP-1 macrophages negated the effects of resveratrol and piceid, indicating that these compounds promote efferocytosis primarily through the upregulation of MFG-E8.

Article Abstract

The process of apoptotic cell clearance by phagocytes, known as efferocytosis, plays an essential role in maintaining homeostasis. Defects in efferocytosis can lead to inflammatory diseases such as atherosclerosis and autoimmune disorders. Therefore, the maintenance and promotion of efferocytosis are considered crucial for preventing these diseases. In this study, we observed that resveratrol, a representative functional food ingredient, and its glycoside, piceid, promoted efferocytosis in both human THP-1 macrophages differentiated with phorbol 12-myristate 13-acetate and peritoneal macrophages from thioglycolate-elicited mice. Resveratrol and piceid significantly increased mRNA expression and protein secretion of MFG-E8 in THP-1 macrophages. Furthermore, the activation of efferocytosis and the increment in MFG-E8 protein secretion caused by resveratrol or piceid treatment were canceled by MFG-E8 knockdown in THP-1 macrophages. In conclusion, we have demonstrated for the first time that resveratrol and piceid promote efferocytosis through the upregulation of MFG-E8 excretion in human THP-1 macrophages.

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Source
http://dx.doi.org/10.1093/bbb/zbae079DOI Listing

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