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The Protocol for the Multi-Ethnic, multi-centre raNdomised controlled trial of a low-energy Diet for improving functional status in heart failure with Preserved ejection fraction (AMEND Preserved).
BMJ Open
January 2025
Department of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester LE3 9QP, UK
Introduction: Heart failure with preserved ejection fraction (HFpEF) is characterised by severe exercise intolerance, particularly in those living with obesity. Low-energy meal-replacement plans (MRPs) have shown significant weight loss and potential cardiac remodelling benefits. This pragmatic randomised trial aims to evaluate the efficacy of MRP-directed weight loss on exercise intolerance, symptoms, quality of life and cardiovascular remodelling in a multiethnic cohort with obesity and HFpEF.
View Article and Find Full Text PDFThe naples prognostic score as a new predictor for heart failure: A cross-sectional study.
Heart Lung
January 2025
Henan University, 379 North Section of Mingli Road, Zhengzhou, China.
Background: The Naples prognostic score (NPS), a novel nutritional and inflammatory index, holds great promise for predicting the prognosis of heart failure (HF), but research on its association with HF outcomes is limited.
Objective: To analyze the relationship between the NPS and the incidence rate and long-term prognosis of HF.
Methods: Participants from the National Health and Nutrition Examination Survey (NHANES) data were allocated into three groups (group 0 (the NPS=0), group 1-2 (the NPS=1-2), and group 3-4 (the NPS=3-4)) based on the NPS level.
The study investigates the effectiveness of immersive virtual reality (VR) as a nonpharmaceutical approach to manage postoperative pain in patients following thoracoscopic surgery. In this single-center, triple-arm pilot randomized controlled trial (RCT), 61 postsurgical patients with a postoperative pain numerical rating scale (NRS) score ≥4 after receiving standard analgesia were included and assigned to either a quantum clinics-VR (QTC-VR) group, a Placebo-VR group, or a control group. The QTC-VR group engaged in a daily 10-minute interactive pain relief 3D-VR program, while the Placebo-VR group watched a daily 10-minute relaxation-based 2D film through VR headsets for three days following surgery.
View Article and Find Full Text PDFVery Early Health Technology Assessment for Potential Predictive Biomarkers in the Treatment of Advanced Non-Small Cell Lung Cancer.
Pharmacoecon Open
January 2025
Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Objectives: Immune checkpoint inhibitor (ICI)-containing treatment is currently prescribed as first-line treatment for all patients with advanced non-small cell lung cancer (NSCLC) without targetable driver mutations. However, only 30-45% of patients show no progression within 12 months after treatment start. Various biomarkers are being studied to save costly and potentially harmful treatment in non-responders.
View Article and Find Full Text PDFIntroducing internal allocation factors for assessing aggregate pesticide exposure across multiple pathways and routes.
J Hazard Mater
January 2025
School of Public Health (Shenzhen), Sun Yat-sen University, Guangdong 510275, China. Electronic address:
In the health risk assessment of pesticides, methods for external exposure assessment have been well developed. However, quantifying the contribution of various exposure pathways or routes to internal dose remains challenging. This study introduced the internal allocation factor (IAF) for 319 pesticides to investigate the impact of different exposure pathways and routes on chemical distribution within the human body.
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