AI Article Synopsis
- A novel method has been introduced for Co(III)-catalyzed C(sp)-H alkenylation, targeting less reactive -protected isoquinolones with 1,4-naphthoquinones.
- The protocol is effective for a variety of isoquinolone substitutions, and studies suggest a five-membered cobaltacycle is formed as an intermediate, indicating a unique reaction pathway.
- The scalability of the reaction has been demonstrated, and the resulting product was successfully used as a chemosensor to detect iron ions.
Article Abstract
A strategy for Co(III)-catalyzed C(sp)-H alkenylation of -protected isoquinolones with 1,4-naphthoquinones has been disclosed. The developed protocol was efficiently applied for diversely substituted isoquinolones. Preliminary mechanistic experiments revealed the involvement of a five-membered cobaltacycle as an intermediate. Deuterium labeling experiments suggested the reversible nature of the C-H activation step. The scale-up reaction was also carried out, and the product was utilized as a chemosensor to detect Fe ions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.4c01686 | DOI Listing |
Publication Analysis
Top Keywords
coiii-catalyzed regioselective
4
regioselective functionalization
4
functionalization isoquinolones
4
isoquinolones naphthoquinones
4
naphthoquinones strategy
4
strategy coiii-catalyzed
4
coiii-catalyzed csp-h
4
csp-h alkenylation
4
alkenylation -protected
4
-protected isoquinolones
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!