We examined the correlation between three different methods of quantification: time to positivity (TTP), log CFU, and an assay to detect differentially detectable (DD Mtb) from three different prospective studies. Participants with DD Mtb have significantly more variation in the CFU/TTP correlation than participants with no DD Mtb ( < 0.001). This may impact the design of early bactericidal activity studies that use TTP as the primary outcome.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232379 | PMC |
| http://dx.doi.org/10.1128/aac.01601-23 | DOI Listing |
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