AI Article Synopsis

  • - The study analyzes preeclampsia outcomes in different US regions, focusing on complications and management of the condition based on data from The Preeclampsia Registry which includes mostly White women (92%) across various regions (Northeast, Midwest, South, and West).
  • - Results reveal that women in the South and Midwest had the highest maximum systolic blood pressure during pregnancy, with Southern women receiving more pre-pregnancy antihypertensives and antenatal steroids, and delivering earlier than their counterparts in other regions.
  • - Regional differences also showed that women in the South experienced higher rates of complications like elevated liver enzymes, and more severe conditions like renal complications and hemolysis were noted in women from the

Article Abstract

This study explores preeclampsia outcomes across US regions and examines regional differences in specific preeclampsia-associated pregnancy complications and disease management. Patient-reported measures were obtained from The Preeclampsia Registry, an open-access database composed of women with at least one pregnancy diagnosed with a hypertensive disorder of pregnancy. Pregnancies and associated outcomes were stratified by US region (Northeast, Midwest, South and West). Among 2,667 pregnancies of which 92% were in White women, maximum systolic blood pressure at any time in pregnancy was highest among women in the South and Midwest (p=0.039). Furthermore, more women in the South received pre-pregnancy antihypertensives (p=0.026) and antenatal steroids (p=0.025) and delivered at an earlier gestational age (p=0.014) compared to women in other regions. Pregnancy complications such as elevated liver enzymes were higher in women in the South (p=0.019), and women in the South and West had additional end-organ damage such as renal complications (p<0.001) and hemolysis (p=0.008) as compared to women in other regions. Further investigation is needed to assess whether healthcare access or policy could be contributing to these regional discrepancies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11142255PMC
http://dx.doi.org/10.1101/2024.05.20.24307230DOI Listing

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