Natural product libraries are crucial to drug development, but large libraries drastically increase the time and cost during initial high throughput screens. Here, we developed a method that leverages liquid chromatography-tandem mass spectrometry spectral similarity to dramatically reduce library size, with minimal bioactive loss. This method offers a broadly applicable strategy for accelerated drug discovery with cost reductions, which enable implementation in resource-limited settings.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11142144 | PMC |
| http://dx.doi.org/10.1101/2024.05.22.595232 | DOI Listing |
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